FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014287776> ?p ?o ?g. }

• W2014287776 endingPage "393" @default.
• W2014287776 startingPage "385" @default.
• W2014287776 abstract "The neuronal nucleus is now widely accepted as playing a vital role in maintaining long-term changes in synaptic effectiveness. To act, however, the nucleus must be appropriately relayed with information regarding the latest round of synaptic plasticity. Several constraints of doing so in a neuron pertain to the often significant spatial distance of synapses from the nucleus and the number of synapses required for such a signal to reach functional levels in the nucleus. Largely based on the sensitivity of transcriptional responses to NMDA receptor antagonists, it has been postulated that the signals are physically relayed by biochemical messengers from the synapse to the nucleus. Alternatively, a second, less often considered but equally viable method of signal transduction may be initiated by action potentials generated proximal to the nucleus, wherefrom the signal can be relayed directly by calcium or indirectly by biochemical second messengers. We consider action potential-dependent signaling to the nucleus to have its own computational advantages over the synapse-to-nucleus signal for some functions. This minireview summarizes the logic and experimental support for these two modes of signaling and attempts to validate the action potential model as playing an important role in transcriptional regulation relating specifically to long-term synaptic plasticity." @default.
• W2014287776 created "2016-06-24" @default.
• W2014287776 creator A5005573844 @default.
• W2014287776 creator A5072870918 @default.
• W2014287776 date "2008-04-01" @default.
• W2014287776 modified "2023-10-18" @default.
• W2014287776 title "Action Potentials: To the Nucleus and Beyond" @default.
• W2014287776 cites W1539043236 @default.
• W2014287776 cites W1581543871 @default.
• W2014287776 cites W1585306115 @default.
• W2014287776 cites W1595570385 @default.
• W2014287776 cites W1598726068 @default.
• W2014287776 cites W1605758816 @default.
• W2014287776 cites W1607671357 @default.
• W2014287776 cites W1624747402 @default.
• W2014287776 cites W1908141284 @default.
• W2014287776 cites W1940772596 @default.
• W2014287776 cites W1946004772 @default.
• W2014287776 cites W1964940783 @default.
• W2014287776 cites W1972172786 @default.
• W2014287776 cites W1972384396 @default.
• W2014287776 cites W1972476811 @default.
• W2014287776 cites W1976530901 @default.
• W2014287776 cites W1981364887 @default.
• W2014287776 cites W1982450493 @default.
• W2014287776 cites W1990501032 @default.
• W2014287776 cites W1991779336 @default.
• W2014287776 cites W1994109113 @default.
• W2014287776 cites W1997278591 @default.
• W2014287776 cites W1998347917 @default.
• W2014287776 cites W2000965799 @default.
• W2014287776 cites W2004277714 @default.
• W2014287776 cites W2005744880 @default.
• W2014287776 cites W2009782005 @default.
• W2014287776 cites W2011182719 @default.
• W2014287776 cites W2013381736 @default.
• W2014287776 cites W2014900949 @default.
• W2014287776 cites W2015701831 @default.
• W2014287776 cites W2019435757 @default.
• W2014287776 cites W2023164168 @default.
• W2014287776 cites W2029815031 @default.
• W2014287776 cites W2033026080 @default.
• W2014287776 cites W2034713698 @default.
• W2014287776 cites W2034998738 @default.
• W2014287776 cites W2035659472 @default.
• W2014287776 cites W2042966900 @default.
• W2014287776 cites W2044116972 @default.
• W2014287776 cites W2050066016 @default.
• W2014287776 cites W2053287773 @default.
• W2014287776 cites W2053861280 @default.
• W2014287776 cites W2056336718 @default.
• W2014287776 cites W2058053468 @default.
• W2014287776 cites W2061405268 @default.
• W2014287776 cites W2063055145 @default.
• W2014287776 cites W2066592391 @default.
• W2014287776 cites W2069469260 @default.
• W2014287776 cites W2071957609 @default.
• W2014287776 cites W2072233684 @default.
• W2014287776 cites W2076312647 @default.
• W2014287776 cites W2077251473 @default.
• W2014287776 cites W2078047436 @default.
• W2014287776 cites W2084746466 @default.
• W2014287776 cites W2085957678 @default.
• W2014287776 cites W2092879602 @default.
• W2014287776 cites W2096397256 @default.
• W2014287776 cites W2112520390 @default.
• W2014287776 cites W2118107253 @default.
• W2014287776 cites W2128103118 @default.
• W2014287776 cites W2147917606 @default.
• W2014287776 cites W2155645083 @default.
• W2014287776 cites W2158037543 @default.
• W2014287776 cites W2161036636 @default.
• W2014287776 cites W2168558032 @default.
• W2014287776 cites W311421437 @default.
• W2014287776 doi "https://doi.org/10.3181/0709-mr-241" @default.
• W2014287776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18367626" @default.
• W2014287776 hasPublicationYear "2008" @default.
• W2014287776 type Work @default.
• W2014287776 sameAs 2014287776 @default.
• W2014287776 citedByCount "27" @default.
• W2014287776 countsByYear W20142877762012 @default.
• W2014287776 countsByYear W20142877762013 @default.
• W2014287776 countsByYear W20142877762014 @default.
• W2014287776 countsByYear W20142877762017 @default.
• W2014287776 countsByYear W20142877762018 @default.
• W2014287776 countsByYear W20142877762019 @default.
• W2014287776 countsByYear W20142877762020 @default.
• W2014287776 countsByYear W20142877762021 @default.
• W2014287776 crossrefType "journal-article" @default.
• W2014287776 hasAuthorship W2014287776A5005573844 @default.
• W2014287776 hasAuthorship W2014287776A5072870918 @default.
• W2014287776 hasConcept C127445978 @default.
• W2014287776 hasConcept C163235415 @default.
• W2014287776 hasConcept C169760540 @default.
• W2014287776 hasConcept C170493617 @default.
• W2014287776 hasConcept C194082555 @default.
• W2014287776 hasConcept C194973443 @default.
• W2014287776 hasConcept C2780723820 @default.

• next