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• W2014287986 abstract "Two new heptaketides, corynesporol (1) and 1-hydroxydehydroherbarin (2), along with herbarin (3) were isolated from an endolichenic fungal strain, Corynespora sp. BA-10763, occurring in the cavern beard lichen Usnea cavernosa. The structures of 1-3 were elucidated from their spectroscopic data. Aerial oxidation of corynesporol (1) yielded herbarin (3). Acetylation of 1 afforded the naphthalene derivative 4, whereas acetylation of 3 gave the corresponding naphthoquinone 6 and dehydroherbarin (5). All compounds were evaluated for their cytotoxicity and ability to inhibit migration of human metastatic breast and prostate cancer cell lines MDA-MB-231 and PC-3M, respectively. Dehydroherbarin (5) inhibited migration of both cell lines at concentrations not toxic to these cell lines. This is the first report of metabolites from an endolichenic fungus." @default.
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• W2014287986 date "2007-11-01" @default.
• W2014287986 modified "2023-09-30" @default.
• W2014287986 title "Heptaketides from <i>Corynespora</i> sp. Inhabiting the Cavern Beard Lichen, <i>Usnea cavernosa</i>: First Report of Metabolites of an Endolichenic Fungus" @default.
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• W2014287986 doi "https://doi.org/10.1021/np070466w" @default.
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