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- W2014294185 abstract "The yeast Saccharomyces cerevisiae is a tractable model organism in which both to explore the molecular mechanisms underlying the generation of disease-associated protein misfolding and to map the cellular responses to potentially toxic misfolded proteins. Specific targets have included proteins which in certain disease states form amyloids and lead to neurodegeneration. Such studies are greatly facilitated by the extensive ‘toolbox’ available to the yeast researcher that provides a range of cell engineering options. Consequently, a number of assays at the cell and molecular level have been set up to report on specific protein misfolding events associated with endogenous or heterologous proteins. One major target is the mammalian prion protein PrP because we know little about what specific sequence and/or structural feature(s) of PrP are important for its conversion to the infectious prion form, PrPSc. Here, using a study of the expression in yeast of fusion proteins comprising the yeast prion protein Sup35 fused to various regions of mouse PrP protein, we show how PrP sequences can direct the formation of non-transmissible amyloids and focus in particular on the role of the mouse octarepeat region. Through this study we illustrate the benefits and limitations of yeast-based models for protein misfolding disorders." @default.
- W2014294185 created "2016-06-24" @default.
- W2014294185 creator A5034027870 @default.
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- W2014294185 creator A5064834508 @default.
- W2014294185 creator A5069855545 @default.
- W2014294185 creator A5073197719 @default.
- W2014294185 date "2012-07-01" @default.
- W2014294185 modified "2023-10-03" @default.
- W2014294185 title "Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions" @default.
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- W2014294185 doi "https://doi.org/10.4161/pri.19214" @default.
- W2014294185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3399540" @default.
- W2014294185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22449853" @default.
- W2014294185 hasPublicationYear "2012" @default.
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