Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014296024> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2014296024 endingPage "121" @default.
- W2014296024 startingPage "115" @default.
- W2014296024 abstract "Glucokinase contributes to the maintenance of blood glucose homeostasis by catalyzing the high Km phosphorylation of glucose in the liver and the pancreatic β cell, the only two tissues known to express this enzyme. Molecular biological studies of the glucokinase gene and its products have advanced our understanding of how this gene is differentially regulated in the liver and β cell. The production of an active glucokinase isoform is determined by both transcriptional and post-transcriptional events. Two different promoter regions that are widely separated in a single glucokinase gene are used to produce glucokinase mRNAs in the liver, pancreatic β cell, and pituitary. The different transcription control regions are tissue-specific in their expression and are differentially regulated. In liver, glucokinase gene expression is regulated by insulin and cAMP, whereas in the β cell it is regulated by glucose. The upstream glucokinase promoter region, which gives rise to the glucokinase mRNA in pituitary and pancreas, is structurally and functionally different from the downstream promoter region, which gives rise to the glucokinase mRNA in liver. The use of distinct promoter regions in a single glucokinase gene enables a different set of transcription factors to be utilized in the liver and islet, thus allowing a functionally similar gene product to be regulated in a manner consistent with the different functions of these two tissues. In addition, the splicing of the glucokinase pre-mRNA is regulated in a tissue-specific manner and can affect the activity of the gene product. This is most apparent in the pituitary where an alternately spliced glucokinase mRNA is produced that does not encode a functional enzyme due to an introduced frameshift." @default.
- W2014296024 created "2016-06-24" @default.
- W2014296024 creator A5018530141 @default.
- W2014296024 date "1992-02-01" @default.
- W2014296024 modified "2023-09-23" @default.
- W2014296024 title "Tissue-Specific regulation of glucokinase gene expression" @default.
- W2014296024 cites W123012959 @default.
- W2014296024 cites W1479842759 @default.
- W2014296024 cites W1486210528 @default.
- W2014296024 cites W1488325657 @default.
- W2014296024 cites W1494992303 @default.
- W2014296024 cites W1516306518 @default.
- W2014296024 cites W1520184516 @default.
- W2014296024 cites W1520889677 @default.
- W2014296024 cites W1598767975 @default.
- W2014296024 cites W1648025923 @default.
- W2014296024 cites W174714445 @default.
- W2014296024 cites W1963836299 @default.
- W2014296024 cites W1971578664 @default.
- W2014296024 cites W2000977514 @default.
- W2014296024 cites W2038963291 @default.
- W2014296024 cites W2047487068 @default.
- W2014296024 cites W2067346786 @default.
- W2014296024 cites W2099545840 @default.
- W2014296024 cites W2116828634 @default.
- W2014296024 cites W2141835056 @default.
- W2014296024 cites W2162953223 @default.
- W2014296024 cites W302580862 @default.
- W2014296024 doi "https://doi.org/10.1002/jcb.240480202" @default.
- W2014296024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1618925" @default.
- W2014296024 hasPublicationYear "1992" @default.
- W2014296024 type Work @default.
- W2014296024 sameAs 2014296024 @default.
- W2014296024 citedByCount "58" @default.
- W2014296024 countsByYear W20142960242012 @default.
- W2014296024 countsByYear W20142960242013 @default.
- W2014296024 countsByYear W20142960242014 @default.
- W2014296024 countsByYear W20142960242015 @default.
- W2014296024 countsByYear W20142960242016 @default.
- W2014296024 countsByYear W20142960242017 @default.
- W2014296024 countsByYear W20142960242019 @default.
- W2014296024 countsByYear W20142960242022 @default.
- W2014296024 countsByYear W20142960242023 @default.
- W2014296024 crossrefType "journal-article" @default.
- W2014296024 hasAuthorship W2014296024A5018530141 @default.
- W2014296024 hasConcept C104317684 @default.
- W2014296024 hasConcept C134018914 @default.
- W2014296024 hasConcept C150194340 @default.
- W2014296024 hasConcept C165864922 @default.
- W2014296024 hasConcept C195286587 @default.
- W2014296024 hasConcept C2777391703 @default.
- W2014296024 hasConcept C2779306644 @default.
- W2014296024 hasConcept C3018667095 @default.
- W2014296024 hasConcept C53345823 @default.
- W2014296024 hasConcept C55493867 @default.
- W2014296024 hasConcept C86803240 @default.
- W2014296024 hasConcept C95444343 @default.
- W2014296024 hasConcept C98335778 @default.
- W2014296024 hasConceptScore W2014296024C104317684 @default.
- W2014296024 hasConceptScore W2014296024C134018914 @default.
- W2014296024 hasConceptScore W2014296024C150194340 @default.
- W2014296024 hasConceptScore W2014296024C165864922 @default.
- W2014296024 hasConceptScore W2014296024C195286587 @default.
- W2014296024 hasConceptScore W2014296024C2777391703 @default.
- W2014296024 hasConceptScore W2014296024C2779306644 @default.
- W2014296024 hasConceptScore W2014296024C3018667095 @default.
- W2014296024 hasConceptScore W2014296024C53345823 @default.
- W2014296024 hasConceptScore W2014296024C55493867 @default.
- W2014296024 hasConceptScore W2014296024C86803240 @default.
- W2014296024 hasConceptScore W2014296024C95444343 @default.
- W2014296024 hasConceptScore W2014296024C98335778 @default.
- W2014296024 hasIssue "2" @default.
- W2014296024 hasLocation W20142960241 @default.
- W2014296024 hasLocation W20142960242 @default.
- W2014296024 hasOpenAccess W2014296024 @default.
- W2014296024 hasPrimaryLocation W20142960241 @default.
- W2014296024 hasRelatedWork W1979231988 @default.
- W2014296024 hasRelatedWork W2013170048 @default.
- W2014296024 hasRelatedWork W2014296024 @default.
- W2014296024 hasRelatedWork W2014876371 @default.
- W2014296024 hasRelatedWork W2069991602 @default.
- W2014296024 hasRelatedWork W2081597640 @default.
- W2014296024 hasRelatedWork W2088411685 @default.
- W2014296024 hasRelatedWork W2137360360 @default.
- W2014296024 hasRelatedWork W2284195039 @default.
- W2014296024 hasRelatedWork W2413687222 @default.
- W2014296024 hasVolume "48" @default.
- W2014296024 isParatext "false" @default.
- W2014296024 isRetracted "false" @default.
- W2014296024 magId "2014296024" @default.
- W2014296024 workType "article" @default.