FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014297535> ?p ?o ?g. }

• W2014297535 abstract "Gabapentin, in clinical use since 1993, is indicated as an adjunctive antiepileptic drug (AED) for treatment of complex partial seizures, with or without secondary generalization, in patients over 12 years of age. Although several cellular actions have been described in the literature, the molecular mechanism(s) of action responsible for the anticonvulsant effect of gabapentin has not been conclusively determined. It is likely that gabapentin has multiple concentration-dependent actions that combine in a unique manner to produce antiepileptic efficacy. The pharmacokinetic properties of this water-soluble, amino-acid AED are generally favorable. Absorption appears to be dependent on transport by the L-system amino acid transporter. Elimination of unmetabolized drug occurs by the renal route. Although its therapeutic range is not well characterized, gabapentin has a broad therapeutic index. This implies that a wide range of doses can be used, based on individual patient needs, without significant limitation due to dose-dependent side effects. Gabapentin has few drug-drug interactions, none of which is clinically limiting. Several studies have demonstrated the long-term efficacy of gabapentin with no systematic evidence of tachyphylaxis. In addition, there is increasing evidence to support the use of gabapentin as monotherapy. Gabapentin is safe and is generally well tolerated. To date, nearly 3 million patients have been treated in studies and in open use without causal relationship to a specific life-threatening organ toxicity. Seizure control superior to that observed in well-controlled trials has been reported at higher doses used in clinical practice and in studies. Therefore, gabapentin dosing must be optimized on an individual basis to achieve an adequate trial of the drug and obtain the best seizure control." @default.
• W2014297535 created "2016-06-24" @default.
• W2014297535 creator A5073513408 @default.
• W2014297535 date "1999-06-01" @default.
• W2014297535 modified "2023-10-16" @default.
• W2014297535 title "Gabapentin in the Management of Convulsive Disorders" @default.
• W2014297535 cites W1535948728 @default.
• W2014297535 cites W1964351581 @default.
• W2014297535 cites W1968565834 @default.
• W2014297535 cites W1969032718 @default.
• W2014297535 cites W1969603700 @default.
• W2014297535 cites W1969998902 @default.
• W2014297535 cites W1971664467 @default.
• W2014297535 cites W1972403208 @default.
• W2014297535 cites W1974861738 @default.
• W2014297535 cites W1976600878 @default.
• W2014297535 cites W1977300182 @default.
• W2014297535 cites W1977826427 @default.
• W2014297535 cites W1982827418 @default.
• W2014297535 cites W1983829988 @default.
• W2014297535 cites W1986396315 @default.
• W2014297535 cites W1987371922 @default.
• W2014297535 cites W1991871005 @default.
• W2014297535 cites W1995716893 @default.
• W2014297535 cites W1995939576 @default.
• W2014297535 cites W2004511526 @default.
• W2014297535 cites W2005300391 @default.
• W2014297535 cites W2009317359 @default.
• W2014297535 cites W2015367379 @default.
• W2014297535 cites W2018671604 @default.
• W2014297535 cites W2019204565 @default.
• W2014297535 cites W2022145302 @default.
• W2014297535 cites W2022163758 @default.
• W2014297535 cites W2023162470 @default.
• W2014297535 cites W2023849457 @default.
• W2014297535 cites W2025962935 @default.
• W2014297535 cites W2033170392 @default.
• W2014297535 cites W2040475489 @default.
• W2014297535 cites W2040767892 @default.
• W2014297535 cites W2062806622 @default.
• W2014297535 cites W2064703133 @default.
• W2014297535 cites W2064735979 @default.
• W2014297535 cites W2069545028 @default.
• W2014297535 cites W2071389662 @default.
• W2014297535 cites W2072738567 @default.
• W2014297535 cites W2073272416 @default.
• W2014297535 cites W2073481704 @default.
• W2014297535 cites W2074144357 @default.
• W2014297535 cites W2079392285 @default.
• W2014297535 cites W2083044207 @default.
• W2014297535 cites W2083622984 @default.
• W2014297535 cites W2084923951 @default.
• W2014297535 cites W2087016115 @default.
• W2014297535 cites W2093961371 @default.
• W2014297535 cites W2095383648 @default.
• W2014297535 cites W2096664748 @default.
• W2014297535 cites W2099703099 @default.
• W2014297535 cites W2103289578 @default.
• W2014297535 cites W2107104194 @default.
• W2014297535 cites W2116471965 @default.
• W2014297535 cites W2128726781 @default.
• W2014297535 cites W2131892548 @default.
• W2014297535 cites W2137264859 @default.
• W2014297535 cites W2137606403 @default.
• W2014297535 cites W2152676437 @default.
• W2014297535 cites W2160649727 @default.
• W2014297535 cites W2164410701 @default.
• W2014297535 cites W2169089411 @default.
• W2014297535 cites W2171978745 @default.
• W2014297535 cites W2300163045 @default.
• W2014297535 cites W4210315740 @default.
• W2014297535 cites W4239074436 @default.
• W2014297535 cites W4247231670 @default.
• W2014297535 cites W83394720 @default.
• W2014297535 doi "https://doi.org/10.1111/j.1528-1157.1999.tb00932.x" @default.
• W2014297535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10530682" @default.
• W2014297535 hasPublicationYear "1999" @default.
• W2014297535 type Work @default.
• W2014297535 sameAs 2014297535 @default.
• W2014297535 citedByCount "63" @default.
• W2014297535 countsByYear W20142975352012 @default.
• W2014297535 countsByYear W20142975352013 @default.
• W2014297535 countsByYear W20142975352014 @default.
• W2014297535 countsByYear W20142975352016 @default.
• W2014297535 countsByYear W20142975352017 @default.
• W2014297535 countsByYear W20142975352018 @default.
• W2014297535 countsByYear W20142975352020 @default.
• W2014297535 countsByYear W20142975352022 @default.
• W2014297535 countsByYear W20142975352023 @default.
• W2014297535 crossrefType "journal-article" @default.
• W2014297535 hasAuthorship W2014297535A5073513408 @default.
• W2014297535 hasBestOaLocation W20142975351 @default.
• W2014297535 hasConcept C112705442 @default.
• W2014297535 hasConcept C118552586 @default.
• W2014297535 hasConcept C142724271 @default.
• W2014297535 hasConcept C147789679 @default.
• W2014297535 hasConcept C168481208 @default.
• W2014297535 hasConcept C185592680 @default.
• W2014297535 hasConcept C19831878 @default.
• W2014297535 hasConcept C204787440 @default.

• next