FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014298924> ?p ?o ?g. }

• W2014298924 abstract "Abstract Background In the process of constructing a dynamic model of a metabolic pathway, a large number of parameters such as kinetic constants and initial metabolite concentrations are required. However, in many cases, experimental determination of these parameters is time-consuming. Therefore, for large-scale modelling, it is essential to develop a method that requires few experimental parameters. The hybrid dynamic/static (HDS) method is a combination of the conventional kinetic representation and metabolic flux analysis (MFA). Since no kinetic information is required in the static module, which consists of MFA, the HDS method may dramatically reduce the number of required parameters. However, no adequate method for developing a hybrid model from experimental data has been proposed. Results In this study, we develop a method for constructing hybrid models based on metabolome data. The method discriminates enzymes into static modules and dynamic modules using metabolite concentration time series data. Enzyme reaction rate time series were estimated from the metabolite concentration time series data and used to distinguish enzymes optimally for the dynamic and static modules. The method was applied to build hybrid models of two microbial central-carbon metabolism systems using simulation results from their dynamic models. Conclusion A protocol to build a hybrid model using metabolome data and a minimal number of kinetic parameters has been developed. The proposed method was successfully applied to the strictly regulated central-carbon metabolism system, demonstrating the practical use of the HDS method, which is designed for computer modelling of metabolic systems." @default.
• W2014298924 created "2016-06-24" @default.
• W2014298924 creator A5015575713 @default.
• W2014298924 creator A5034211199 @default.
• W2014298924 creator A5087130713 @default.
• W2014298924 date "2007-05-20" @default.
• W2014298924 modified "2023-09-27" @default.
• W2014298924 title "Distinguishing enzymes using metabolome data for the hybrid dynamic/static method" @default.
• W2014298924 cites W1535241806 @default.
• W2014298924 cites W1549912426 @default.
• W2014298924 cites W1652041254 @default.
• W2014298924 cites W1739295766 @default.
• W2014298924 cites W1912803728 @default.
• W2014298924 cites W1966534566 @default.
• W2014298924 cites W1967214691 @default.
• W2014298924 cites W1967542684 @default.
• W2014298924 cites W1974511160 @default.
• W2014298924 cites W1985096217 @default.
• W2014298924 cites W1986562177 @default.
• W2014298924 cites W1989039684 @default.
• W2014298924 cites W1998034857 @default.
• W2014298924 cites W2007728693 @default.
• W2014298924 cites W2012557331 @default.
• W2014298924 cites W2017551827 @default.
• W2014298924 cites W2025277814 @default.
• W2014298924 cites W2033692581 @default.
• W2014298924 cites W2050858598 @default.
• W2014298924 cites W2053339983 @default.
• W2014298924 cites W2054592691 @default.
• W2014298924 cites W2059145118 @default.
• W2014298924 cites W2075609067 @default.
• W2014298924 cites W2076761602 @default.
• W2014298924 cites W2088343152 @default.
• W2014298924 cites W2099688399 @default.
• W2014298924 cites W2117453669 @default.
• W2014298924 cites W2118893325 @default.
• W2014298924 cites W2121008927 @default.
• W2014298924 cites W2123067735 @default.
• W2014298924 cites W2135809413 @default.
• W2014298924 cites W2139632350 @default.
• W2014298924 cites W2152607628 @default.
• W2014298924 cites W2159628188 @default.
• W2014298924 cites W2169104686 @default.
• W2014298924 cites W2170825071 @default.
• W2014298924 cites W2397343268 @default.
• W2014298924 doi "https://doi.org/10.1186/1742-4682-4-19" @default.
• W2014298924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1892778" @default.
• W2014298924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17511884" @default.
• W2014298924 hasPublicationYear "2007" @default.
• W2014298924 type Work @default.
• W2014298924 sameAs 2014298924 @default.
• W2014298924 citedByCount "10" @default.
• W2014298924 countsByYear W20142989242013 @default.
• W2014298924 countsByYear W20142989242014 @default.
• W2014298924 countsByYear W20142989242015 @default.
• W2014298924 countsByYear W20142989242020 @default.
• W2014298924 crossrefType "journal-article" @default.
• W2014298924 hasAuthorship W2014298924A5015575713 @default.
• W2014298924 hasAuthorship W2014298924A5034211199 @default.
• W2014298924 hasAuthorship W2014298924A5087130713 @default.
• W2014298924 hasBestOaLocation W20142989241 @default.
• W2014298924 hasConcept C135870905 @default.
• W2014298924 hasConcept C143724316 @default.
• W2014298924 hasConcept C151730666 @default.
• W2014298924 hasConcept C152662350 @default.
• W2014298924 hasConcept C160941953 @default.
• W2014298924 hasConcept C17744445 @default.
• W2014298924 hasConcept C181199279 @default.
• W2014298924 hasConcept C185592680 @default.
• W2014298924 hasConcept C186060115 @default.
• W2014298924 hasConcept C192989942 @default.
• W2014298924 hasConcept C199539241 @default.
• W2014298924 hasConcept C21565614 @default.
• W2014298924 hasConcept C2776359362 @default.
• W2014298924 hasConcept C2777477808 @default.
• W2014298924 hasConcept C41008148 @default.
• W2014298924 hasConcept C55493867 @default.
• W2014298924 hasConcept C60644358 @default.
• W2014298924 hasConcept C62231903 @default.
• W2014298924 hasConcept C70721500 @default.
• W2014298924 hasConcept C86803240 @default.
• W2014298924 hasConcept C94625758 @default.
• W2014298924 hasConceptScore W2014298924C135870905 @default.
• W2014298924 hasConceptScore W2014298924C143724316 @default.
• W2014298924 hasConceptScore W2014298924C151730666 @default.
• W2014298924 hasConceptScore W2014298924C152662350 @default.
• W2014298924 hasConceptScore W2014298924C160941953 @default.
• W2014298924 hasConceptScore W2014298924C17744445 @default.
• W2014298924 hasConceptScore W2014298924C181199279 @default.
• W2014298924 hasConceptScore W2014298924C185592680 @default.
• W2014298924 hasConceptScore W2014298924C186060115 @default.
• W2014298924 hasConceptScore W2014298924C192989942 @default.
• W2014298924 hasConceptScore W2014298924C199539241 @default.
• W2014298924 hasConceptScore W2014298924C21565614 @default.
• W2014298924 hasConceptScore W2014298924C2776359362 @default.
• W2014298924 hasConceptScore W2014298924C2777477808 @default.
• W2014298924 hasConceptScore W2014298924C41008148 @default.
• W2014298924 hasConceptScore W2014298924C55493867 @default.
• W2014298924 hasConceptScore W2014298924C60644358 @default.
• W2014298924 hasConceptScore W2014298924C62231903 @default.

• next