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• W2014299424 abstract "It is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self-proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed, we found autoantigens to contain significantly more single nucleotide polymorphisms (SNP) than other human genes do. Our finding may offer an explanation for autoimmune responses through allogeneic exposure. Besides other contributing factors in autoimmunity, SNP may represent an essential prerequisite for the primary induction of an autoimmune response." @default.
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• W2014299424 date "2005-01-03" @default.
• W2014299424 modified "2023-09-26" @default.
• W2014299424 title "Single nucleotide polymorphisms as a prerequisite for autoantigens" @default.
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• W2014299424 doi "https://doi.org/10.1002/eji.200425481" @default.
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