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- W2014301711 abstract "Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that F. gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F. gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections." @default.
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- W2014301711 date "2013-04-01" @default.
- W2014301711 modified "2023-10-17" @default.
- W2014301711 title "Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide" @default.
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- W2014301711 doi "https://doi.org/10.1016/j.ejmech.2012.12.038" @default.
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