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- W2014303640 abstract "Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg(-1)) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10(7) CFU/mL; NCU116-M, 10(8) CFU/mL; NCU116-H, 10(9) CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation." @default.
- W2014303640 created "2016-06-24" @default.
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- W2014303640 date "2015-03-30" @default.
- W2014303640 modified "2023-10-13" @default.
- W2014303640 title "Effect of<i>Lactobacillus plantarum</i>NCU116 on loperamide-induced constipation in mice" @default.
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- W2014303640 doi "https://doi.org/10.3109/09637486.2015.1024204" @default.
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