FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014304850> ?p ?o ?g. }

• W2014304850 endingPage "1267" @default.
• W2014304850 startingPage "1257" @default.
• W2014304850 abstract "R(+)‐alpha‐lipoic acid is a natural occurring compound that acts as an essential cofactor for certain dehydrogenase complexes. The redox couple alpha‐lipoic acid/dihydrolipoic acid possesses potent antioxidant activity. Exogenous racemic alpha‐lipoic acid orally administered for the symptomatic treatment of diabetic polyneuropathy is readily and nearly completely absorbed, with a limited absolute bioavailability of about 30% caused by high hepatic extraction. Although the pharmacokinetics of the parent drug have been well characterized in humans, relatively little is known regarding the excretion of alpha‐lipoic acid and the pharmacokinetics of any metabolites in humans. In the present study, plasma concentration‐time courses, urinary excreted amounts, and pharmacokinetic parameters of alpha‐lipoic acid metabolites were evaluated in 9 healthy volunteers after multiple once‐daily oral administration of 600 mg racemic alpha‐lipoic acid. The primary metabolic pathways of alpha‐lipoic acid in man, S‐methylation and β‐oxidation, were quantitatively confirmed by an HPLC‐electrochemical assay newly established prior to the beginning of this study. Major circulating metabolites were the S‐methylated β‐oxidation products 4,6‐bismethylthio‐hexanoic acid and 2,4‐bismethylthio‐butanoic acid, whereas its conjugated forms accounted for the major portion excreted in urine. There was no statistically significant difference in the pharmacokinetic parameters C max , AUC, and t max between day 1 and day 4. Despite the prolonged half‐lives of the major metabolites compared to the parent drug, no evidence of accumulation was found. Mean values of 12.4% of the administered dose were recovered in the urine after 24 hours as the sum of alpha‐lipoic acid and its metabolites. The results of the present study revealed that urinary excretion of alpha‐lipoic acid and five of its main metabolites does not play a significant role in the elimination of alpha‐lipoic acid. Therefore, biliary excretion, further electrochemically inactive degradation products, and complete utilization of alpha‐lipoic acid as a primary substrate in the endogenous metabolism should be considered ." @default.
• W2014304850 created "2016-06-24" @default.
• W2014304850 creator A5000991422 @default.
• W2014304850 creator A5051358167 @default.
• W2014304850 creator A5057924098 @default.
• W2014304850 creator A5083638044 @default.
• W2014304850 date "2003-11-01" @default.
• W2014304850 modified "2023-10-17" @default.
• W2014304850 title "Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha-Lipoic Acid following Oral Administration in Healthy Volunteers" @default.
• W2014304850 cites W1965696818 @default.
• W2014304850 cites W1969759573 @default.
• W2014304850 cites W1977121598 @default.
• W2014304850 cites W1978042177 @default.
• W2014304850 cites W1990305582 @default.
• W2014304850 cites W1994622933 @default.
• W2014304850 cites W1996111334 @default.
• W2014304850 cites W2000959775 @default.
• W2014304850 cites W2003939788 @default.
• W2014304850 cites W2047106058 @default.
• W2014304850 cites W2049861842 @default.
• W2014304850 cites W2053814042 @default.
• W2014304850 cites W2055361714 @default.
• W2014304850 cites W2060072386 @default.
• W2014304850 cites W2060498821 @default.
• W2014304850 cites W2070263356 @default.
• W2014304850 cites W2075578721 @default.
• W2014304850 cites W2076340616 @default.
• W2014304850 cites W2076762989 @default.
• W2014304850 cites W2077792640 @default.
• W2014304850 cites W2078110423 @default.
• W2014304850 cites W2085601513 @default.
• W2014304850 cites W2097278760 @default.
• W2014304850 cites W2102514120 @default.
• W2014304850 cites W2127251573 @default.
• W2014304850 cites W2886334118 @default.
• W2014304850 doi "https://doi.org/10.1177/0091270003258654" @default.
• W2014304850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14551180" @default.
• W2014304850 hasPublicationYear "2003" @default.
• W2014304850 type Work @default.
• W2014304850 sameAs 2014304850 @default.
• W2014304850 citedByCount "133" @default.
• W2014304850 countsByYear W20143048502012 @default.
• W2014304850 countsByYear W20143048502013 @default.
• W2014304850 countsByYear W20143048502014 @default.
• W2014304850 countsByYear W20143048502015 @default.
• W2014304850 countsByYear W20143048502016 @default.
• W2014304850 countsByYear W20143048502017 @default.
• W2014304850 countsByYear W20143048502018 @default.
• W2014304850 countsByYear W20143048502019 @default.
• W2014304850 countsByYear W20143048502020 @default.
• W2014304850 countsByYear W20143048502021 @default.
• W2014304850 countsByYear W20143048502022 @default.
• W2014304850 countsByYear W20143048502023 @default.
• W2014304850 crossrefType "journal-article" @default.
• W2014304850 hasAuthorship W2014304850A5000991422 @default.
• W2014304850 hasAuthorship W2014304850A5051358167 @default.
• W2014304850 hasAuthorship W2014304850A5057924098 @default.
• W2014304850 hasAuthorship W2014304850A5083638044 @default.
• W2014304850 hasConcept C10146269 @default.
• W2014304850 hasConcept C112705442 @default.
• W2014304850 hasConcept C181389837 @default.
• W2014304850 hasConcept C185592680 @default.
• W2014304850 hasConcept C2777056448 @default.
• W2014304850 hasConcept C2777477808 @default.
• W2014304850 hasConcept C2778004101 @default.
• W2014304850 hasConcept C2779491571 @default.
• W2014304850 hasConcept C2780026642 @default.
• W2014304850 hasConcept C2908636690 @default.
• W2014304850 hasConcept C2910140794 @default.
• W2014304850 hasConcept C55493867 @default.
• W2014304850 hasConcept C62231903 @default.
• W2014304850 hasConcept C71924100 @default.
• W2014304850 hasConcept C98274493 @default.
• W2014304850 hasConceptScore W2014304850C10146269 @default.
• W2014304850 hasConceptScore W2014304850C112705442 @default.
• W2014304850 hasConceptScore W2014304850C181389837 @default.
• W2014304850 hasConceptScore W2014304850C185592680 @default.
• W2014304850 hasConceptScore W2014304850C2777056448 @default.
• W2014304850 hasConceptScore W2014304850C2777477808 @default.
• W2014304850 hasConceptScore W2014304850C2778004101 @default.
• W2014304850 hasConceptScore W2014304850C2779491571 @default.
• W2014304850 hasConceptScore W2014304850C2780026642 @default.
• W2014304850 hasConceptScore W2014304850C2908636690 @default.
• W2014304850 hasConceptScore W2014304850C2910140794 @default.
• W2014304850 hasConceptScore W2014304850C55493867 @default.
• W2014304850 hasConceptScore W2014304850C62231903 @default.
• W2014304850 hasConceptScore W2014304850C71924100 @default.
• W2014304850 hasConceptScore W2014304850C98274493 @default.
• W2014304850 hasIssue "11" @default.
• W2014304850 hasLocation W20143048501 @default.
• W2014304850 hasLocation W20143048502 @default.
• W2014304850 hasOpenAccess W2014304850 @default.
• W2014304850 hasPrimaryLocation W20143048501 @default.
• W2014304850 hasRelatedWork W1984814061 @default.
• W2014304850 hasRelatedWork W2171382661 @default.
• W2014304850 hasRelatedWork W2171677115 @default.
• W2014304850 hasRelatedWork W2359798641 @default.
• W2014304850 hasRelatedWork W2364354571 @default.

• next