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• W2014308187 abstract "This review summarizes the history of research on mesenchymal-epithelial interactions in prostatic development from the first studies in 1970 to the present. From this study we have learned that prostatic development requires a reciprocal interaction between epithelium and mesenchyme in which urogenital sinus mesenchyme induces and patterns epithelial development and differentiation, while developing prostatic epithelium induces and patterns mesenchymal differentiation into smooth muscle and other resident cell types in the stroma. Prostatic development requires androgen action mediated by the androgen receptor (AR). Through analysis of tissue recombinants composed of wild-type and AR-null epithelium and mesenchyme, we have learned that many androgenic effects on prostatic epithelium do not require epithelial AR, but instead are elicited by the paracrine action of AR-positive mesenchyme. Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme." @default.
• W2014308187 created "2016-06-24" @default.
• W2014308187 creator A5065328069 @default.
• W2014308187 date "2008-07-01" @default.
• W2014308187 modified "2023-10-18" @default.
• W2014308187 title "Mesenchymal–epithelial interactions: past, present, and future" @default.
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• W2014308187 doi "https://doi.org/10.1111/j.1432-0436.2008.00290.x" @default.
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