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- W2014308977 abstract "Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography. Three compounds were fair to very potent competitive antagonists of substance P on three bioassays, i.e., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea. [Arg6,D-Trp10]SP(6-11) is a reasonable antagonist in all three bioassays and [D-Pro4,D-Trp7,9]SP(4-11) is a very potent competitive antagonist with pA2 values ranging around 6.0." @default.
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- W2014308977 date "1982-11-01" @default.
- W2014308977 modified "2023-10-16" @default.
- W2014308977 title "Synthesis and biological activities of substance P antagonists" @default.
- W2014308977 doi "https://doi.org/10.1021/jm00353a008" @default.
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