FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014311922> ?p ?o ?g. }

• W2014311922 endingPage "1226" @default.
• W2014311922 startingPage "1219" @default.
• W2014311922 abstract "Targeting drug formulations to specific tissues and releasing the bioactive content in response to a certain stimuli remains a significant challenge in the field of biomedical science. We have developed a nanovehicle that can be used to deliver “drugs” to “specific” tissues. For this, we have simultaneously modified the surface of the nanovehicle with “drugs” and “tissue-specific ligands”. The “tissue-specific ligands” will target the nanovehicle to the correct tissue and release the “drug” of interest in response to specific stimuli. We have synthesised a “lactose surface-modified gold nanovehicle” to target liver cells and release the model fluorescent drug (coumarin derivative) in response to the differential glutathione concentration (between blood plasma and liver cells). Lactose is used as the liver-specific targeting ligand given the abundance of l-galactose receptors in hepatic cells. The coumarin derivative is used as a fluorescent tag as well as a linker for the attachment of various biologically relevant molecules. The model delivery system is compatible with a host of different ligands and hence could be used to target other tissues as well in future. The synthesised nanovehicle was found to be non-toxic to cultured human cell lines even at elevated non-physiological concentrations as high as 100 μg/mL. We discover that the synthesised gold-based nanovehicle shows considerable stability at low extracellular glutathione concentrations; however coumarin is selectively released at high hepatic glutathione concentration." @default.
• W2014311922 created "2016-06-24" @default.
• W2014311922 creator A5022070578 @default.
• W2014311922 creator A5044311499 @default.
• W2014311922 creator A5044515118 @default.
• W2014311922 creator A5084068934 @default.
• W2014311922 date "2013-08-09" @default.
• W2014311922 modified "2023-10-17" @default.
• W2014311922 title "Synthesis of a Smart Gold Nano‐vehicle for Liver Specific Drug Delivery" @default.
• W2014311922 cites W1972063621 @default.
• W2014311922 cites W1981381342 @default.
• W2014311922 cites W1981441986 @default.
• W2014311922 cites W1983480912 @default.
• W2014311922 cites W1985522024 @default.
• W2014311922 cites W1990968236 @default.
• W2014311922 cites W1994265576 @default.
• W2014311922 cites W2000640075 @default.
• W2014311922 cites W2003753401 @default.
• W2014311922 cites W2004415603 @default.
• W2014311922 cites W2013300088 @default.
• W2014311922 cites W2017407214 @default.
• W2014311922 cites W2019110612 @default.
• W2014311922 cites W2035869908 @default.
• W2014311922 cites W2036828387 @default.
• W2014311922 cites W2047732005 @default.
• W2014311922 cites W2052955020 @default.
• W2014311922 cites W2055944585 @default.
• W2014311922 cites W2061719532 @default.
• W2014311922 cites W2075585703 @default.
• W2014311922 cites W2088765230 @default.
• W2014311922 cites W2121056096 @default.
• W2014311922 cites W2141168419 @default.
• W2014311922 cites W2344762599 @default.
• W2014311922 cites W4256043273 @default.
• W2014311922 doi "https://doi.org/10.1208/s12249-013-9999-0" @default.
• W2014311922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3755171" @default.
• W2014311922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23934434" @default.
• W2014311922 hasPublicationYear "2013" @default.
• W2014311922 type Work @default.
• W2014311922 sameAs 2014311922 @default.
• W2014311922 citedByCount "13" @default.
• W2014311922 countsByYear W20143119222014 @default.
• W2014311922 countsByYear W20143119222015 @default.
• W2014311922 countsByYear W20143119222016 @default.
• W2014311922 countsByYear W20143119222017 @default.
• W2014311922 countsByYear W20143119222020 @default.
• W2014311922 countsByYear W20143119222021 @default.
• W2014311922 countsByYear W20143119222022 @default.
• W2014311922 crossrefType "journal-article" @default.
• W2014311922 hasAuthorship W2014311922A5022070578 @default.
• W2014311922 hasAuthorship W2014311922A5044311499 @default.
• W2014311922 hasAuthorship W2014311922A5044515118 @default.
• W2014311922 hasAuthorship W2014311922A5084068934 @default.
• W2014311922 hasBestOaLocation W20143119222 @default.
• W2014311922 hasConcept C111919701 @default.
• W2014311922 hasConcept C116569031 @default.
• W2014311922 hasConcept C12554922 @default.
• W2014311922 hasConcept C170493617 @default.
• W2014311922 hasConcept C178790620 @default.
• W2014311922 hasConcept C181199279 @default.
• W2014311922 hasConcept C185592680 @default.
• W2014311922 hasConcept C2779820397 @default.
• W2014311922 hasConcept C2780035454 @default.
• W2014311922 hasConcept C2780557392 @default.
• W2014311922 hasConcept C2781338262 @default.
• W2014311922 hasConcept C41008148 @default.
• W2014311922 hasConcept C538909803 @default.
• W2014311922 hasConcept C55493867 @default.
• W2014311922 hasConcept C86803240 @default.
• W2014311922 hasConcept C98274493 @default.
• W2014311922 hasConceptScore W2014311922C111919701 @default.
• W2014311922 hasConceptScore W2014311922C116569031 @default.
• W2014311922 hasConceptScore W2014311922C12554922 @default.
• W2014311922 hasConceptScore W2014311922C170493617 @default.
• W2014311922 hasConceptScore W2014311922C178790620 @default.
• W2014311922 hasConceptScore W2014311922C181199279 @default.
• W2014311922 hasConceptScore W2014311922C185592680 @default.
• W2014311922 hasConceptScore W2014311922C2779820397 @default.
• W2014311922 hasConceptScore W2014311922C2780035454 @default.
• W2014311922 hasConceptScore W2014311922C2780557392 @default.
• W2014311922 hasConceptScore W2014311922C2781338262 @default.
• W2014311922 hasConceptScore W2014311922C41008148 @default.
• W2014311922 hasConceptScore W2014311922C538909803 @default.
• W2014311922 hasConceptScore W2014311922C55493867 @default.
• W2014311922 hasConceptScore W2014311922C86803240 @default.
• W2014311922 hasConceptScore W2014311922C98274493 @default.
• W2014311922 hasIssue "3" @default.
• W2014311922 hasLocation W20143119221 @default.
• W2014311922 hasLocation W20143119222 @default.
• W2014311922 hasLocation W20143119223 @default.
• W2014311922 hasLocation W20143119224 @default.
• W2014311922 hasOpenAccess W2014311922 @default.
• W2014311922 hasPrimaryLocation W20143119221 @default.
• W2014311922 hasRelatedWork W1969321973 @default.
• W2014311922 hasRelatedWork W2072273640 @default.
• W2014311922 hasRelatedWork W2084267068 @default.
• W2014311922 hasRelatedWork W2331451851 @default.
• W2014311922 hasRelatedWork W2399730475 @default.

• next