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- W2014313931 abstract "GE37468A is a new thiazolyl peptide antibiotic acting on Elongation Factor Tu, produced by fermentation of Streptomyces sp. ATCC 55365. The low (< 10 mg/liter) and poorly reproducible antibiotic productivity of the original soil isolate hampered the development of a scalable fermentation process. A tenfold increase of GE37468A productivity was achieved by selection of spontaneous morphochromatic variants, which appeared at high frequency in the wild type population. The higher producing ATCC 55365/O/5 colony was tyrosinase defective and blocked in the aerial mycelium differentiation (Amy-Mel- phenotype). The fermentation process of this stable and purified strain was rapidly optimized to achieve a further fourfold improvement in a fed-batch process." @default.
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- W2014313931 date "1996-01-01" @default.
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- W2014313931 title "Antibiotic GE37468A: A New Inhibitor of Bacterial Protein Synthesis. III. Strain and Fermentation Study." @default.
- W2014313931 doi "https://doi.org/10.7164/antibiotics.49.880" @default.
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