Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014322488> ?p ?o ?g. }
- W2014322488 endingPage "e12978" @default.
- W2014322488 startingPage "e12978" @default.
- W2014322488 abstract "Background Mycobacterium tuberculosis phoP mutant SO2 derived from a clinical isolate was shown to be attenuated in mouse bone marrow-derived macrophages and in vivo mouse infection model and has demonstrated a high potential as attenuated vaccine candidate against tuberculosis. Methodology/Principal Findings In this study, we analyze the adhesion and the intracellular growth and trafficking of SO2 in human macrophages. Our results indicate an enhanced adhesion to phagocitic cells and impaired intracellular replication of SO2 in both monocyte-derived macrophages and human cell line THP-1 in comparison with the wild type strain, consistent with murine model. Intracellular trafficking analysis in human THP-1 cells suggest that attenuation of SO2 within macrophages could be due to an impaired ability to block phagosome-lysosome fusion compared with the parental M. tuberculosis strain. No differences were found between SO2 and the wild-type strains in the release and mycobacterial susceptibility to nitric oxide (NO) produced by infected macrophages. Conclusions/Significance SO2 has enhanced ability to bind human macrophages and differs in intracellular trafficking as to wild-type M. tuberculosis. The altered lipid profile expression of the phoP mutant SO2 and its inability to secrete ESAT-6 is discussed." @default.
- W2014322488 created "2016-06-24" @default.
- W2014322488 creator A5001255521 @default.
- W2014322488 creator A5015029255 @default.
- W2014322488 creator A5044673843 @default.
- W2014322488 creator A5046108606 @default.
- W2014322488 creator A5088332737 @default.
- W2014322488 date "2010-09-24" @default.
- W2014322488 modified "2023-10-01" @default.
- W2014322488 title "Interactions of Attenuated Mycobacterium tuberculosis phoP Mutant with Human Macrophages" @default.
- W2014322488 cites W1606308841 @default.
- W2014322488 cites W1875522162 @default.
- W2014322488 cites W1914611833 @default.
- W2014322488 cites W1926098097 @default.
- W2014322488 cites W1939948552 @default.
- W2014322488 cites W1967255828 @default.
- W2014322488 cites W1968593986 @default.
- W2014322488 cites W1971661340 @default.
- W2014322488 cites W1974309182 @default.
- W2014322488 cites W1975045527 @default.
- W2014322488 cites W1976656389 @default.
- W2014322488 cites W1977574443 @default.
- W2014322488 cites W1980094540 @default.
- W2014322488 cites W1985564274 @default.
- W2014322488 cites W1987706044 @default.
- W2014322488 cites W1995062416 @default.
- W2014322488 cites W2003156840 @default.
- W2014322488 cites W2006252982 @default.
- W2014322488 cites W2008893774 @default.
- W2014322488 cites W2013908690 @default.
- W2014322488 cites W2036091801 @default.
- W2014322488 cites W2036218860 @default.
- W2014322488 cites W2036420717 @default.
- W2014322488 cites W2040650178 @default.
- W2014322488 cites W2041687573 @default.
- W2014322488 cites W2041992882 @default.
- W2014322488 cites W2042411369 @default.
- W2014322488 cites W2049667078 @default.
- W2014322488 cites W2055532157 @default.
- W2014322488 cites W2063037576 @default.
- W2014322488 cites W2066520670 @default.
- W2014322488 cites W2086083146 @default.
- W2014322488 cites W2099795721 @default.
- W2014322488 cites W2100219870 @default.
- W2014322488 cites W2101666067 @default.
- W2014322488 cites W2104335702 @default.
- W2014322488 cites W2105787630 @default.
- W2014322488 cites W2123768471 @default.
- W2014322488 cites W2136886125 @default.
- W2014322488 cites W2142075333 @default.
- W2014322488 cites W2157559696 @default.
- W2014322488 cites W2159106464 @default.
- W2014322488 cites W2160131728 @default.
- W2014322488 cites W2160170449 @default.
- W2014322488 cites W2161034058 @default.
- W2014322488 cites W2164250944 @default.
- W2014322488 cites W169716701 @default.
- W2014322488 cites W2738669660 @default.
- W2014322488 doi "https://doi.org/10.1371/journal.pone.0012978" @default.
- W2014322488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2945763" @default.
- W2014322488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20885976" @default.
- W2014322488 hasPublicationYear "2010" @default.
- W2014322488 type Work @default.
- W2014322488 sameAs 2014322488 @default.
- W2014322488 citedByCount "38" @default.
- W2014322488 countsByYear W20143224882012 @default.
- W2014322488 countsByYear W20143224882013 @default.
- W2014322488 countsByYear W20143224882014 @default.
- W2014322488 countsByYear W20143224882015 @default.
- W2014322488 countsByYear W20143224882016 @default.
- W2014322488 countsByYear W20143224882017 @default.
- W2014322488 countsByYear W20143224882018 @default.
- W2014322488 countsByYear W20143224882021 @default.
- W2014322488 countsByYear W20143224882023 @default.
- W2014322488 crossrefType "journal-article" @default.
- W2014322488 hasAuthorship W2014322488A5001255521 @default.
- W2014322488 hasAuthorship W2014322488A5015029255 @default.
- W2014322488 hasAuthorship W2014322488A5044673843 @default.
- W2014322488 hasAuthorship W2014322488A5046108606 @default.
- W2014322488 hasAuthorship W2014322488A5088332737 @default.
- W2014322488 hasBestOaLocation W20143224881 @default.
- W2014322488 hasConcept C104317684 @default.
- W2014322488 hasConcept C142724271 @default.
- W2014322488 hasConcept C143065580 @default.
- W2014322488 hasConcept C153726182 @default.
- W2014322488 hasConcept C159047783 @default.
- W2014322488 hasConcept C161478664 @default.
- W2014322488 hasConcept C202751555 @default.
- W2014322488 hasConcept C203014093 @default.
- W2014322488 hasConcept C204258353 @default.
- W2014322488 hasConcept C207583985 @default.
- W2014322488 hasConcept C2777975735 @default.
- W2014322488 hasConcept C2779244956 @default.
- W2014322488 hasConcept C2781069245 @default.
- W2014322488 hasConcept C2781184567 @default.
- W2014322488 hasConcept C49039625 @default.
- W2014322488 hasConcept C54355233 @default.
- W2014322488 hasConcept C55493867 @default.