Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014323289> ?p ?o ?g. }
- W2014323289 endingPage "14977" @default.
- W2014323289 startingPage "14973" @default.
- W2014323289 abstract "The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is associated with posttranslational modifications of p53, some of which are mediated by the ATM protein kinase. However, these modifications alone may not account in full for p53 stabilization. p53's stability and activity are negatively regulated by the oncoprotein MDM2, whose gene is activated by p53. Conceivably, p53 function may be modulated by modifications of MDM2 as well. We show here that after treatment of cells with ionizing radiation or a radiomimetic chemical, but not UV radiation, MDM2 is phosphorylated rapidly in an ATM-dependent manner. This phosphorylation is independent of p53 and the DNA-dependent protein kinase. Furthermore, MDM2 is directly phosphorylated by ATM in vitro. These findings suggest that in response to DNA strand breaks, ATM may promote p53 activity and stability by mediating simultaneous phosphorylation of both partners of the p53-MDM2 autoregulatory feedback loop." @default.
- W2014323289 created "2016-06-24" @default.
- W2014323289 creator A5036387444 @default.
- W2014323289 creator A5040465895 @default.
- W2014323289 creator A5047689535 @default.
- W2014323289 creator A5061128919 @default.
- W2014323289 creator A5063387040 @default.
- W2014323289 creator A5086398854 @default.
- W2014323289 date "1999-12-21" @default.
- W2014323289 modified "2023-10-15" @default.
- W2014323289 title "Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage" @default.
- W2014323289 cites W142794159 @default.
- W2014323289 cites W143775612 @default.
- W2014323289 cites W1495729285 @default.
- W2014323289 cites W1575731774 @default.
- W2014323289 cites W1582386710 @default.
- W2014323289 cites W1640195411 @default.
- W2014323289 cites W1643545782 @default.
- W2014323289 cites W1644206514 @default.
- W2014323289 cites W1760383320 @default.
- W2014323289 cites W1822460389 @default.
- W2014323289 cites W1966115284 @default.
- W2014323289 cites W1971966311 @default.
- W2014323289 cites W1972566109 @default.
- W2014323289 cites W1974640412 @default.
- W2014323289 cites W1978518304 @default.
- W2014323289 cites W1979669293 @default.
- W2014323289 cites W1986179131 @default.
- W2014323289 cites W1991494214 @default.
- W2014323289 cites W1994163195 @default.
- W2014323289 cites W1995211857 @default.
- W2014323289 cites W2003236156 @default.
- W2014323289 cites W2014170738 @default.
- W2014323289 cites W2028019289 @default.
- W2014323289 cites W2028210102 @default.
- W2014323289 cites W2045552152 @default.
- W2014323289 cites W2052598236 @default.
- W2014323289 cites W2056530510 @default.
- W2014323289 cites W2060810889 @default.
- W2014323289 cites W2062612693 @default.
- W2014323289 cites W2079706088 @default.
- W2014323289 cites W2082979850 @default.
- W2014323289 cites W2084374650 @default.
- W2014323289 cites W2089574530 @default.
- W2014323289 cites W2092675732 @default.
- W2014323289 cites W2092722802 @default.
- W2014323289 cites W2100448419 @default.
- W2014323289 cites W2101719051 @default.
- W2014323289 cites W2130728712 @default.
- W2014323289 cites W2145679711 @default.
- W2014323289 cites W2149013144 @default.
- W2014323289 cites W2155640249 @default.
- W2014323289 cites W2156299289 @default.
- W2014323289 cites W2158107656 @default.
- W2014323289 cites W2166213130 @default.
- W2014323289 cites W2168924996 @default.
- W2014323289 cites W2169830490 @default.
- W2014323289 cites W2473589128 @default.
- W2014323289 cites W349619315 @default.
- W2014323289 cites W4212962560 @default.
- W2014323289 cites W4248611167 @default.
- W2014323289 cites W4296142355 @default.
- W2014323289 doi "https://doi.org/10.1073/pnas.96.26.14973" @default.
- W2014323289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24757" @default.
- W2014323289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10611322" @default.
- W2014323289 hasPublicationYear "1999" @default.
- W2014323289 type Work @default.
- W2014323289 sameAs 2014323289 @default.
- W2014323289 citedByCount "423" @default.
- W2014323289 countsByYear W20143232892012 @default.
- W2014323289 countsByYear W20143232892013 @default.
- W2014323289 countsByYear W20143232892014 @default.
- W2014323289 countsByYear W20143232892015 @default.
- W2014323289 countsByYear W20143232892016 @default.
- W2014323289 countsByYear W20143232892017 @default.
- W2014323289 countsByYear W20143232892018 @default.
- W2014323289 countsByYear W20143232892019 @default.
- W2014323289 countsByYear W20143232892020 @default.
- W2014323289 countsByYear W20143232892021 @default.
- W2014323289 countsByYear W20143232892022 @default.
- W2014323289 countsByYear W20143232892023 @default.
- W2014323289 crossrefType "journal-article" @default.
- W2014323289 hasAuthorship W2014323289A5036387444 @default.
- W2014323289 hasAuthorship W2014323289A5040465895 @default.
- W2014323289 hasAuthorship W2014323289A5047689535 @default.
- W2014323289 hasAuthorship W2014323289A5061128919 @default.
- W2014323289 hasAuthorship W2014323289A5063387040 @default.
- W2014323289 hasAuthorship W2014323289A5086398854 @default.
- W2014323289 hasBestOaLocation W20143232892 @default.
- W2014323289 hasConcept C104317684 @default.
- W2014323289 hasConcept C11960822 @default.
- W2014323289 hasConcept C134935766 @default.
- W2014323289 hasConcept C143425029 @default.
- W2014323289 hasConcept C184235292 @default.
- W2014323289 hasConcept C2776192174 @default.
- W2014323289 hasConcept C502942594 @default.
- W2014323289 hasConcept C552990157 @default.
- W2014323289 hasConcept C55493867 @default.