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- W2014326785 abstract "The importance of catecholamine secretion in the cold was studied by treating rats placed at 27°C or 4°C with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, H2254, a tyrosine and phenylalanine hydroxylase inhibitor, or trimethyldopa, a phenylalanine hydroxylase inhibitor. Alpha-methyl-p-tyrosine produced the largest fall in tissue noradrenaline. H2254 and trimethyldopa, although causing a moderate fall in noradrenaline stores at 27°, were more effective in the cold room. Alpha-methyl-p-tyrosine and trimethyldopa depressed noradrenaline excretion and increased adrenaline release in the cold. The adrenaline served as a “second line of defense” evoked by the noradrenaline decrease. Adrenodemedullated rats given alpha-methyl-p-tyrosine or trimethyldopa at 4° showed a high rate of mortality. H2254 lowered tissue and urinary levels of noradrenaline in the cold but failed to produce hypothermia and death in intact or adrenodemedullated rats. It is suggested that other actions of H2254, such as an inhibition of catechol-o-methyl transferase, may have contributed to the maintenance of normothermia." @default.
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- W2014326785 date "1968-04-01" @default.
- W2014326785 modified "2023-09-26" @default.
- W2014326785 title "Influence of cold exposure on catecholamine depleting actions of hydroxylase inhibitors" @default.
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- W2014326785 doi "https://doi.org/10.1016/0014-2999(68)90046-0" @default.
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