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- W2014328862 abstract "The first-pass effect results from metabolism during the first liver passage of a drug given by mouth. The metabolism is described by the Michaelis-Menten equation, but the integrated form of the Michaelis-Menten equation has no explicit solution for concentration and its handling requires a computer. However, the presented nonlinear equation of the first-pass effect is an explicit integration of the Michaelis-Menten equation and involves only general mathematics. However, the problem of evaluating the Michaelis-Menten constants Vm and Km is not resolved. Therefore, linear equations are also derived, which correspond to previous clearance models." @default.
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- W2014328862 date "1981-02-01" @default.
- W2014328862 modified "2023-10-18" @default.
- W2014328862 title "First-Pass Effect: Nonlinear Concept Comprising an Explicit Solution of Integrated Michaelis-Menten Equation" @default.
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- W2014328862 doi "https://doi.org/10.1002/jps.2600700221" @default.
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