FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014330166> ?p ?o ?g. }

• W2014330166 endingPage "721" @default.
• W2014330166 startingPage "711" @default.
• W2014330166 abstract "Adenosine A(2A) receptor (A(2A)R) agonists synergize with Escherichia coli (E. coli) LPS [toll-like receptor (TLR)4 agonist] to up-regulate vascular endothelial growth factor (VEGF) expression in murine macrophages. Here, we demonstrate that TLR2, TLR7, and TLR9, but not TLR3 and TLR5 agonists, also synergize with A(2A)R agonists and adenosine to up-regulate VEGF, while simultaneously strongly down-regulating TNFalpha expression. In the absence of adenosine or A(2A)R agonists, Porphyromonas gingivalis (P. gingivalis) LPS and PAM(3)CAG (TLR2 agonists), resiquimod (R848) (TLR7 agonist), and non-methylated CpG DNA (TLR9 agonist) strongly up-regulate TNFalpha expression, with no effect on VEGF. In the presence of adenosine or A(2A)R agonists, but not A(1)R agonists, TLR2, 4, 7, and 9 agonists strongly up-regulate VEGF expression, while simultaneously down-regulating TNFalpha. C57BL/10ScN (TLR4 deletion mutant) macrophages produce TNFalpha in response to TLR2, 3, 7, and 9 agonists, but not the TLR4 agonist E. coli LPS. With adenosine or A(2A)R agonists, TLR2, 7, and 9, but not TLR4 agonists, also synergistically up-regulate VEGF, while down-regulating TNFalpha expression. Polyinosinic-polycytidilic acid (poly(I:C)) (TLR3 agonist) stimulates TNFalpha expression in macrophages from both C57BL/10ScSn and C57BL/10ScN mice, but has little effect on VEGF expression in the presence of adenosine or A(2A)R agonists. R-flagellins from Serratia marcescens (S. marcescens) and Salmonella muenchen (S. muenchen) do not stimulate TNFalpha expression in either C57BL/10ScSn or C57BL10/ScN mice, and have no effect on VEGF production in the presence of adenosine or A(2A)R agonists. While adenosine and A(2A)R agonists strongly down-regulate TNFalpha protein expression induced by TLR2, 3, 4, 7, and 9 agonists, TNFalpha mRNA and NF-kappaB activation are not reduced. We propose a novel signaling pathway in murine macrophages involving synergy between TLRs 2, 4, 7, and 9 and A(2A)Rs, that up-regulates VEGF and down-regulates TNFalpha expression, thus acting as an angiogenic switch. This angiogenic switch may play an important role in ischemia when TLR agonists are present, providing an interface between innate immunity and wound healing." @default.
• W2014330166 created "2016-06-24" @default.
• W2014330166 creator A5006418968 @default.
• W2014330166 creator A5031612429 @default.
• W2014330166 creator A5040110369 @default.
• W2014330166 creator A5041046556 @default.
• W2014330166 creator A5048760718 @default.
• W2014330166 creator A5069134694 @default.
• W2014330166 creator A5078491855 @default.
• W2014330166 date "2003-08-01" @default.
• W2014330166 modified "2023-10-14" @default.
• W2014330166 title "An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors" @default.
• W2014330166 cites W114449204 @default.
• W2014330166 cites W1480509123 @default.
• W2014330166 cites W1514540900 @default.
• W2014330166 cites W1517718326 @default.
• W2014330166 cites W1519633296 @default.
• W2014330166 cites W1529648101 @default.
• W2014330166 cites W1536635467 @default.
• W2014330166 cites W1565635064 @default.
• W2014330166 cites W1575186397 @default.
• W2014330166 cites W1585401061 @default.
• W2014330166 cites W1621954734 @default.
• W2014330166 cites W1655860314 @default.
• W2014330166 cites W1815757713 @default.
• W2014330166 cites W1886164324 @default.
• W2014330166 cites W189480869 @default.
• W2014330166 cites W1930598094 @default.
• W2014330166 cites W1940453590 @default.
• W2014330166 cites W1956304128 @default.
• W2014330166 cites W1966932577 @default.
• W2014330166 cites W1971248512 @default.
• W2014330166 cites W1972261522 @default.
• W2014330166 cites W1972584214 @default.
• W2014330166 cites W1972776583 @default.
• W2014330166 cites W1974165456 @default.
• W2014330166 cites W1977648783 @default.
• W2014330166 cites W1978926805 @default.
• W2014330166 cites W1985712533 @default.
• W2014330166 cites W1989081076 @default.
• W2014330166 cites W1990332976 @default.
• W2014330166 cites W1993761825 @default.
• W2014330166 cites W1994238688 @default.
• W2014330166 cites W2001586504 @default.
• W2014330166 cites W2004348481 @default.
• W2014330166 cites W2006874202 @default.
• W2014330166 cites W2012438506 @default.
• W2014330166 cites W2013510760 @default.
• W2014330166 cites W2016730049 @default.
• W2014330166 cites W2018131877 @default.
• W2014330166 cites W2020672090 @default.
• W2014330166 cites W2021271099 @default.
• W2014330166 cites W2022369905 @default.
• W2014330166 cites W2022468880 @default.
• W2014330166 cites W2027518725 @default.
• W2014330166 cites W2031462278 @default.
• W2014330166 cites W2037490361 @default.
• W2014330166 cites W2045074917 @default.
• W2014330166 cites W2047376205 @default.
• W2014330166 cites W2048320764 @default.
• W2014330166 cites W2053043145 @default.
• W2014330166 cites W2067299834 @default.
• W2014330166 cites W2067684973 @default.
• W2014330166 cites W2069981713 @default.
• W2014330166 cites W2073565085 @default.
• W2014330166 cites W2076361525 @default.
• W2014330166 cites W2081182178 @default.
• W2014330166 cites W2081406767 @default.
• W2014330166 cites W2085609942 @default.
• W2014330166 cites W2100272171 @default.
• W2014330166 cites W2106392016 @default.
• W2014330166 cites W2110827592 @default.
• W2014330166 cites W2115893060 @default.
• W2014330166 cites W2120227455 @default.
• W2014330166 cites W2123840402 @default.
• W2014330166 cites W2129319296 @default.
• W2014330166 cites W2129667982 @default.
• W2014330166 cites W2132993740 @default.
• W2014330166 cites W2140174959 @default.
• W2014330166 cites W2143343444 @default.
• W2014330166 cites W2152163440 @default.
• W2014330166 cites W2156445477 @default.
• W2014330166 cites W2162656620 @default.
• W2014330166 cites W2163496617 @default.
• W2014330166 cites W2225709026 @default.
• W2014330166 cites W2292093022 @default.
• W2014330166 cites W2338560476 @default.
• W2014330166 cites W2408030517 @default.
• W2014330166 cites W4296981756 @default.
• W2014330166 doi "https://doi.org/10.1016/s0002-9440(10)63698-x" @default.
• W2014330166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1868201" @default.
• W2014330166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12875990" @default.
• W2014330166 hasPublicationYear "2003" @default.
• W2014330166 type Work @default.
• W2014330166 sameAs 2014330166 @default.
• W2014330166 citedByCount "249" @default.
• W2014330166 countsByYear W20143301662012 @default.
• W2014330166 countsByYear W20143301662013 @default.

• next