Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014333610> ?p ?o ?g. }
- W2014333610 abstract "Significance Long-held tenets in the field of signal transduction are that G proteins are activated exclusively by G protein-coupled receptors and that growth factor receptor tyrosine kinases (RTKs) do not have the wherewithal to do the same. In this work we created fluorescent biosensors derived from the multimodular signal transducer Gα-interacting vesicle-associated protein (GIV), an unusual protein that binds RTKs and activates G proteins, and used them in FRET and bimolecular fluorescent complementation assays to visualize RTK–GIV–G protein signaling complexes directly in single living cells. These studies not only provide evidence that GIV serves as a platform for transactivation of G proteins by growth factor RTKs but also illuminate the spatial and temporal dynamics of such noncanonical G protein signaling." @default.
- W2014333610 created "2016-06-24" @default.
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- W2014333610 date "2015-02-17" @default.
- W2014333610 modified "2023-09-26" @default.
- W2014333610 title "Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors" @default.
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- W2014333610 doi "https://doi.org/10.1073/pnas.1420140112" @default.
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