Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014335736> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2014335736 endingPage "769" @default.
- W2014335736 startingPage "761" @default.
- W2014335736 abstract "It is now established that the pancreatic islet cells derive from precursors present in the pancreatic ducts. These precursor cells as well as the factors that influence their differentiation to mature insulin-secreting beta-islet cells are nevertheless not elucidated yet. However, the large number of similarities existing between beta-cells and neuronal cells led to the suggestion that these two different cell types may be sensitive to the same growth and differentiation factors, for example, nerve growth factor (NGF), which is important for the differentiation and survival of several neurons. It was previously demonstrated that the high affinity NGF receptor, Trk-A, which is sufficient for NGF signal transduction, is expressed in different beta-cell lines and in normal rat islet cells in primary culture. The aim of this study was therefore to examine whether the Trk-A receptor is present in vivo in the rat pancreas during development and in adult life. By double immunofluorescence analysis using anti-Trk-A/antiinsulin or anti-Trk-A/antiglucagon antibodies on pancreatic sections of adult rats, it is demonstrated that the Trk-A protein is present in the beta- and not in the alpha-islet cells of adult rat pancreas. No Trk-A immunostaining was observed in the exocrine pancreas or in the pancreatic ducts of adult pancreas. Interestingly, the pattern of Trk-A immunolocalization in the pancreas is different during fetal life, when Trk-A immunostaining is observed in the pancreatic ductular cells and undetectable in both beta- and alpha-islet cells. During late prenatal and early postnatal life, Trk-A immunostaining is present in the islet cells, although weaker than in adult rats, and progressively decreases in the pancreatic ducts, as pancreatic maturation progresses. The intensity and localization of the Trk-A immunostaining in the rat pancreas are therefore developmentally regulated." @default.
- W2014335736 created "2016-06-24" @default.
- W2014335736 creator A5007387317 @default.
- W2014335736 creator A5041588029 @default.
- W2014335736 creator A5065441382 @default.
- W2014335736 creator A5071542344 @default.
- W2014335736 date "1995-02-01" @default.
- W2014335736 modified "2023-10-14" @default.
- W2014335736 title "In vivo presence of the high affinity nerve growth factor receptor Trk-A in the rat pancreas: differential localization during pancreatic development." @default.
- W2014335736 doi "https://doi.org/10.1210/endo.136.2.7835308" @default.
- W2014335736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7835308" @default.
- W2014335736 hasPublicationYear "1995" @default.
- W2014335736 type Work @default.
- W2014335736 sameAs 2014335736 @default.
- W2014335736 citedByCount "43" @default.
- W2014335736 countsByYear W20143357362013 @default.
- W2014335736 countsByYear W20143357362016 @default.
- W2014335736 countsByYear W20143357362019 @default.
- W2014335736 crossrefType "journal-article" @default.
- W2014335736 hasAuthorship W2014335736A5007387317 @default.
- W2014335736 hasAuthorship W2014335736A5041588029 @default.
- W2014335736 hasAuthorship W2014335736A5065441382 @default.
- W2014335736 hasAuthorship W2014335736A5071542344 @default.
- W2014335736 hasConcept C126322002 @default.
- W2014335736 hasConcept C134018914 @default.
- W2014335736 hasConcept C134139212 @default.
- W2014335736 hasConcept C150903083 @default.
- W2014335736 hasConcept C165220095 @default.
- W2014335736 hasConcept C170493617 @default.
- W2014335736 hasConcept C204232928 @default.
- W2014335736 hasConcept C207001950 @default.
- W2014335736 hasConcept C2778423431 @default.
- W2014335736 hasConcept C2778764654 @default.
- W2014335736 hasConcept C2779306644 @default.
- W2014335736 hasConcept C2779855799 @default.
- W2014335736 hasConcept C4224716 @default.
- W2014335736 hasConcept C71924100 @default.
- W2014335736 hasConcept C86803240 @default.
- W2014335736 hasConcept C92020748 @default.
- W2014335736 hasConceptScore W2014335736C126322002 @default.
- W2014335736 hasConceptScore W2014335736C134018914 @default.
- W2014335736 hasConceptScore W2014335736C134139212 @default.
- W2014335736 hasConceptScore W2014335736C150903083 @default.
- W2014335736 hasConceptScore W2014335736C165220095 @default.
- W2014335736 hasConceptScore W2014335736C170493617 @default.
- W2014335736 hasConceptScore W2014335736C204232928 @default.
- W2014335736 hasConceptScore W2014335736C207001950 @default.
- W2014335736 hasConceptScore W2014335736C2778423431 @default.
- W2014335736 hasConceptScore W2014335736C2778764654 @default.
- W2014335736 hasConceptScore W2014335736C2779306644 @default.
- W2014335736 hasConceptScore W2014335736C2779855799 @default.
- W2014335736 hasConceptScore W2014335736C4224716 @default.
- W2014335736 hasConceptScore W2014335736C71924100 @default.
- W2014335736 hasConceptScore W2014335736C86803240 @default.
- W2014335736 hasConceptScore W2014335736C92020748 @default.
- W2014335736 hasIssue "2" @default.
- W2014335736 hasLocation W20143357361 @default.
- W2014335736 hasLocation W20143357362 @default.
- W2014335736 hasOpenAccess W2014335736 @default.
- W2014335736 hasPrimaryLocation W20143357361 @default.
- W2014335736 hasRelatedWork W1951162574 @default.
- W2014335736 hasRelatedWork W2014335736 @default.
- W2014335736 hasRelatedWork W2017980006 @default.
- W2014335736 hasRelatedWork W2049316221 @default.
- W2014335736 hasRelatedWork W2062334532 @default.
- W2014335736 hasRelatedWork W2064538767 @default.
- W2014335736 hasRelatedWork W2077402733 @default.
- W2014335736 hasRelatedWork W2089866099 @default.
- W2014335736 hasRelatedWork W2144747390 @default.
- W2014335736 hasRelatedWork W4249694249 @default.
- W2014335736 hasVolume "136" @default.
- W2014335736 isParatext "false" @default.
- W2014335736 isRetracted "false" @default.
- W2014335736 magId "2014335736" @default.
- W2014335736 workType "article" @default.