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• W2014338380 endingPage "24" @default.
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• W2014338380 abstract "Electrophysiological methods have been practised in ophthalmology for many years. In 1992 Sutter and Tran introduced the multifocal technique, which enables the recording of electrical currents derived from very localized parts of the retina. Multifocal electroretinography (mfERG) has been used in animal studies, mostly in rodents and non-human primates, but also in pigs. However, the latter has been performed without the use of retinal photographic monitoring during mfERG recording, thus rendering an exact correlation with specific retinal changes impossible. By modifying the experimental set-up, as well as the settings of the mfERG software, reproducible recordings on anaesthetized pigs were obtained during continuous photographic monitoring of the fundus area. The mfERG response obtained from the porcine retina was characterized by the same three amplitude deflections as described in studies on human retinas: N1, P1 and N2. Multifocal ERG responses derived from within the visual streak of the porcine retina were characterized by significantly faster implicit times and higher amplitudes for all three peaks, compared with responses derived from within the inferior, less cone-rich part of the retina. The spatial resolution of the developed mfERG protocol enables the detection of retinal areas of reduced functionality of a size ≥ 1.2 mm. In the acute and late phases, significant reductions in all peak amplitudes were observed after retinal laser photocoagulation. Implicit times were less influenced by the treatment. This corresponded with marked central tissue destruction found histologically. The following surgical procedures necessitate surgical access to the subretinal space: vitrectomy; retinal detachment bleb formation; retinal diathermia, and retinotomy. Extending the size of these interventions, which is necessary if subsequent surgery is to be carried out in the subretinal space, caused a statistically non-significant tendency towards reduced amplitudes within the first postoperative week. Only retinal diathermia significantly prolonged the implicit time of one peak (N1) after 1 week of observation. The functional consequences of the surgical procedures were all found to cause reversible changes in the mfERG within a 6-week observation period. Thus, these findings indicate that in experimental subretinal surgery on pigs, any mfERG change found 6 weeks postoperatively could be attributed to factors other than surgical access to the subretinal space. This renders the described animal model and mfERG-protocol applicable in future experiments regarding pathology, treatment, surgery and stem cell transplantation in the retina as well as in the subretinal space of the porcine eye." @default.
• W2014338380 created "2016-06-24" @default.
• W2014338380 creator A5051608230 @default.
• W2014338380 date "2007-05-30" @default.
• W2014338380 modified "2023-09-26" @default.
• W2014338380 title "Multifocal electroretinography (mfERG) in porcine eyes: establishment, sensitivity and functional implications of induced retinal lesions" @default.
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• W2014338380 doi "https://doi.org/10.1111/j.1600-0420.2007.00952.x" @default.
• W2014338380 hasPublicationYear "2007" @default.
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