FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014339600> ?p ?o ?g. }

• W2014339600 endingPage "279" @default.
• W2014339600 startingPage "272" @default.
• W2014339600 abstract "The binding mechanism of molecular interaction between 5-(ethoxycarbonyl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (a dihydropyrimidinones derivative, EMPD) and human serum albumin (HSA) was studied using spectroscopic methods and modeling technique. The quenching mechanism was investigated in terms of the binding constants and the basic thermodynamic parameters. The results of spectroscopic measurements suggested that EMPD have a strong ability to quench the intrinsic fluorescence of HSA through static quenching procedure. The drug–protein complex was stabilized by hydrophobic forces and hydrogen bonding as indicated from the thermodynamic parameters and synchronous fluorescence spectra, which was consistent with the results of molecular docking and accessible surface area calculation. Competitive experiments indicated that a displacement of warfarin by EMPD, which revealed that the binding site of EMPD to HSA was located at the subdomains IIA. The distance between the donor and the acceptor was 4.85 nm as estimated according to Förster's theory of non-radiation energy transfer. The effect of metal ions on the binding constants was also investigated. The results indicated that the binding constants between EMPD and HSA increased in the presence of common metal ions." @default.
• W2014339600 created "2016-06-24" @default.
• W2014339600 creator A5016678508 @default.
• W2014339600 creator A5020514362 @default.
• W2014339600 creator A5035278528 @default.
• W2014339600 creator A5063026471 @default.
• W2014339600 date "2011-05-01" @default.
• W2014339600 modified "2023-10-16" @default.
• W2014339600 title "Exploring the binding mechanism of dihydropyrimidinones to human serum albumin: Spectroscopic and molecular modeling techniques" @default.
• W2014339600 cites W1596809281 @default.
• W2014339600 cites W1964900539 @default.
• W2014339600 cites W1968931762 @default.
• W2014339600 cites W1973238993 @default.
• W2014339600 cites W1976436661 @default.
• W2014339600 cites W1976570404 @default.
• W2014339600 cites W1977848104 @default.
• W2014339600 cites W1982022971 @default.
• W2014339600 cites W1983339797 @default.
• W2014339600 cites W1983477962 @default.
• W2014339600 cites W1986542232 @default.
• W2014339600 cites W1991049348 @default.
• W2014339600 cites W1994866772 @default.
• W2014339600 cites W2001573970 @default.
• W2014339600 cites W2008166117 @default.
• W2014339600 cites W2010031591 @default.
• W2014339600 cites W2013847826 @default.
• W2014339600 cites W2014477053 @default.
• W2014339600 cites W2029136818 @default.
• W2014339600 cites W2032813998 @default.
• W2014339600 cites W2040184556 @default.
• W2014339600 cites W2042634918 @default.
• W2014339600 cites W2047396169 @default.
• W2014339600 cites W2048052059 @default.
• W2014339600 cites W2051274703 @default.
• W2014339600 cites W2055992184 @default.
• W2014339600 cites W2062462127 @default.
• W2014339600 cites W2063563180 @default.
• W2014339600 cites W2064461522 @default.
• W2014339600 cites W2068402952 @default.
• W2014339600 cites W2070813301 @default.
• W2014339600 cites W2075705506 @default.
• W2014339600 cites W2079828643 @default.
• W2014339600 cites W2079948746 @default.
• W2014339600 cites W2084925214 @default.
• W2014339600 cites W2091732745 @default.
• W2014339600 cites W2095376206 @default.
• W2014339600 cites W2132707438 @default.
• W2014339600 cites W2163408090 @default.
• W2014339600 cites W4241161331 @default.
• W2014339600 doi "https://doi.org/10.1016/j.colsurfb.2011.01.016" @default.
• W2014339600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21306879" @default.
• W2014339600 hasPublicationYear "2011" @default.
• W2014339600 type Work @default.
• W2014339600 sameAs 2014339600 @default.
• W2014339600 citedByCount "52" @default.
• W2014339600 countsByYear W20143396002012 @default.
• W2014339600 countsByYear W20143396002013 @default.
• W2014339600 countsByYear W20143396002014 @default.
• W2014339600 countsByYear W20143396002015 @default.
• W2014339600 countsByYear W20143396002016 @default.
• W2014339600 countsByYear W20143396002017 @default.
• W2014339600 countsByYear W20143396002018 @default.
• W2014339600 countsByYear W20143396002019 @default.
• W2014339600 countsByYear W20143396002020 @default.
• W2014339600 countsByYear W20143396002021 @default.
• W2014339600 countsByYear W20143396002022 @default.
• W2014339600 countsByYear W20143396002023 @default.
• W2014339600 crossrefType "journal-article" @default.
• W2014339600 hasAuthorship W2014339600A5016678508 @default.
• W2014339600 hasAuthorship W2014339600A5020514362 @default.
• W2014339600 hasAuthorship W2014339600A5035278528 @default.
• W2014339600 hasAuthorship W2014339600A5063026471 @default.
• W2014339600 hasConcept C107824862 @default.
• W2014339600 hasConcept C112887158 @default.
• W2014339600 hasConcept C121332964 @default.
• W2014339600 hasConcept C121745418 @default.
• W2014339600 hasConcept C147597530 @default.
• W2014339600 hasConcept C147789679 @default.
• W2014339600 hasConcept C178790620 @default.
• W2014339600 hasConcept C185592680 @default.
• W2014339600 hasConcept C2778597219 @default.
• W2014339600 hasConcept C32786932 @default.
• W2014339600 hasConcept C32909587 @default.
• W2014339600 hasConcept C43617362 @default.
• W2014339600 hasConcept C55493867 @default.
• W2014339600 hasConcept C59593255 @default.
• W2014339600 hasConcept C62520636 @default.
• W2014339600 hasConcept C8010536 @default.
• W2014339600 hasConcept C91881484 @default.
• W2014339600 hasConcept C96305047 @default.
• W2014339600 hasConceptScore W2014339600C107824862 @default.
• W2014339600 hasConceptScore W2014339600C112887158 @default.
• W2014339600 hasConceptScore W2014339600C121332964 @default.
• W2014339600 hasConceptScore W2014339600C121745418 @default.
• W2014339600 hasConceptScore W2014339600C147597530 @default.
• W2014339600 hasConceptScore W2014339600C147789679 @default.
• W2014339600 hasConceptScore W2014339600C178790620 @default.
• W2014339600 hasConceptScore W2014339600C185592680 @default.

• next