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- W2014339767 abstract "Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication. Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication." @default.
- W2014339767 created "2016-06-24" @default.
- W2014339767 creator A5006284228 @default.
- W2014339767 date "2010-06-01" @default.
- W2014339767 modified "2023-09-27" @default.
- W2014339767 title "The interface between transcription and mechanisms maintaining genome integrity" @default.
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- W2014339767 doi "https://doi.org/10.1016/j.tibs.2010.02.001" @default.
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