Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014345129> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2014345129 abstract "The binding of iralukast to plasma (or serum) proteins and to erythrocytes was studied in vitro, at +37 degrees C, using the erythrocyte partitioning method (EPM) and/or ultrafiltration (UF) with 14C-labelled iralukast. Iralukast was highly bound in human and animal serum (>99%). Similar bound fraction values were obtained with the two methods: in whole human plasma (or serum) 99.8% (EPM) and 99.9% (UF), in albumin solution 99.8% (EPM and UF), in high density lipoprotein solution 97.3% (EPM) and 98.3% (UF), and in low density lipoprotein solution 97.2% (EPM) and 98.8% (UF). Moreover, the erythrocyte partitioning method allowed the evaluation of other binding parameters. The binding capacity (l/micromol) of proteins equalled 35 for low density lipoproteins, 3.6 for high density lipoproteins, 1.0 for albumin, 0.78 for alpha-1-acid glycoprotein, and 0.03 for gamma globulins. In whole blood, iralukast was distributed between plasma and erythrocytes in the proportion (%) 90/10. At physiological protein concentrations, iralukast was primarily bound to albumin (79%)." @default.
- W2014345129 created "2016-06-24" @default.
- W2014345129 creator A5052497721 @default.
- W2014345129 creator A5054836705 @default.
- W2014345129 creator A5071289541 @default.
- W2014345129 date "1999-01-01" @default.
- W2014345129 modified "2023-10-18" @default.
- W2014345129 title "Binding of iralukast to serum proteins and erythrocytes: measurements using ultrafiltration and an erythrocyte partitioning method" @default.
- W2014345129 cites W1970226406 @default.
- W2014345129 cites W1985902720 @default.
- W2014345129 cites W1990424107 @default.
- W2014345129 cites W1993926418 @default.
- W2014345129 cites W2028895699 @default.
- W2014345129 cites W2040567541 @default.
- W2014345129 doi "https://doi.org/10.1016/s0928-0987(98)00025-6" @default.
- W2014345129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9845802" @default.
- W2014345129 hasPublicationYear "1999" @default.
- W2014345129 type Work @default.
- W2014345129 sameAs 2014345129 @default.
- W2014345129 citedByCount "7" @default.
- W2014345129 countsByYear W20143451292018 @default.
- W2014345129 countsByYear W20143451292020 @default.
- W2014345129 crossrefType "journal-article" @default.
- W2014345129 hasAuthorship W2014345129A5052497721 @default.
- W2014345129 hasAuthorship W2014345129A5054836705 @default.
- W2014345129 hasAuthorship W2014345129A5071289541 @default.
- W2014345129 hasConcept C108625454 @default.
- W2014345129 hasConcept C146543888 @default.
- W2014345129 hasConcept C165616093 @default.
- W2014345129 hasConcept C185592680 @default.
- W2014345129 hasConcept C203014093 @default.
- W2014345129 hasConcept C2776125364 @default.
- W2014345129 hasConcept C2778163477 @default.
- W2014345129 hasConcept C2779620165 @default.
- W2014345129 hasConcept C2780072125 @default.
- W2014345129 hasConcept C30787643 @default.
- W2014345129 hasConcept C43617362 @default.
- W2014345129 hasConcept C50817676 @default.
- W2014345129 hasConcept C51639874 @default.
- W2014345129 hasConcept C55493867 @default.
- W2014345129 hasConcept C81358767 @default.
- W2014345129 hasConcept C86803240 @default.
- W2014345129 hasConceptScore W2014345129C108625454 @default.
- W2014345129 hasConceptScore W2014345129C146543888 @default.
- W2014345129 hasConceptScore W2014345129C165616093 @default.
- W2014345129 hasConceptScore W2014345129C185592680 @default.
- W2014345129 hasConceptScore W2014345129C203014093 @default.
- W2014345129 hasConceptScore W2014345129C2776125364 @default.
- W2014345129 hasConceptScore W2014345129C2778163477 @default.
- W2014345129 hasConceptScore W2014345129C2779620165 @default.
- W2014345129 hasConceptScore W2014345129C2780072125 @default.
- W2014345129 hasConceptScore W2014345129C30787643 @default.
- W2014345129 hasConceptScore W2014345129C43617362 @default.
- W2014345129 hasConceptScore W2014345129C50817676 @default.
- W2014345129 hasConceptScore W2014345129C51639874 @default.
- W2014345129 hasConceptScore W2014345129C55493867 @default.
- W2014345129 hasConceptScore W2014345129C81358767 @default.
- W2014345129 hasConceptScore W2014345129C86803240 @default.
- W2014345129 hasLocation W20143451291 @default.
- W2014345129 hasLocation W20143451292 @default.
- W2014345129 hasOpenAccess W2014345129 @default.
- W2014345129 hasPrimaryLocation W20143451291 @default.
- W2014345129 hasRelatedWork W1511283813 @default.
- W2014345129 hasRelatedWork W1533279890 @default.
- W2014345129 hasRelatedWork W2014345129 @default.
- W2014345129 hasRelatedWork W2018385296 @default.
- W2014345129 hasRelatedWork W2037095201 @default.
- W2014345129 hasRelatedWork W2078344335 @default.
- W2014345129 hasRelatedWork W2080084127 @default.
- W2014345129 hasRelatedWork W2162632962 @default.
- W2014345129 hasRelatedWork W2313379919 @default.
- W2014345129 hasRelatedWork W2470924071 @default.
- W2014345129 isParatext "false" @default.
- W2014345129 isRetracted "false" @default.
- W2014345129 magId "2014345129" @default.
- W2014345129 workType "article" @default.