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• W2014348568 abstract "Background: Contemporary heart failure (HF) therapies have not resulted in improved outcome among HF patients with preserved left ventricular (LV) function. We sought to evaluate the differential effect of LV function on long term mortality following hospitalization for acute HF patients in a real world setting. Methods: All-cause mortality at 4 years following hospitalization for HF was assessed by LV ejection fraction (LVEF, categorized as preserved [≥50%], mildly- [40%-49%], moderately- [30%-39%], and severely-[<30%] reduced) among 1620 patients enrolled in the Heart Failure Survey in Israel. Results: Among study patients 30% had preserved LVEF, and 20%, 25%, and 25%, had mild, moderate, and severe, reductions in LVEF, respectively. The cumulative mortality rate at 4 years was highest among those with reduced LVEF, and similar between patients with preserved LV function compared with mild or moderate reductions on LVEF (Figure). Multivariate analysis showed that patients with severely reduced LVEF had a 20% (p=0.03) increase in 4-year mortality rate compared with preserved LVEF patients, whereas mild or moderate reduction in LVEF had no impact on mortality rates (HR=0.91 [p=0.33] and 1.02 [p=0.85], respectively). Independent predictors of 4-year mortality among patients with preserved LVEF included age > 75 (HR=2.15, p<0.001), NYHA class III-IV vs. I-II (HR=1.54, p<0.001) and glomerular filtration rate ≤ 50 ml/min (HR=1.82, p<0.001), while systolic blood pressure>140 mmHg had a protective effect (HR=0.68, p=0.001). Cumulative Survival by LVEF Class Cumulative Survival by LVEF Class Conclusion: Heart failure patients with preserved LVEF experience similar long-term mortality rates as patients with mild or moderate reductions in LV function. Specific clinical and laboratory characteristics identified increased risk for long-term mortality in this population." @default.
• W2014348568 created "2016-06-24" @default.
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• W2014348568 date "2013-08-02" @default.
• W2014348568 modified "2023-10-16" @default.
• W2014348568 title "Differential effect of left ventricular ejection fraction on long term mortality in patients hospitalized with acute heart failure. Data from the HFSIS 2003 registry" @default.
• W2014348568 doi "https://doi.org/10.1093/eurheartj/eht308.p1494" @default.
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