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- W2014350022 abstract "In the immune system, apoptosis is involved in intrathymic elimination of self-reactive thymocytes and in peripheral T cell tolerance to exogenous antigens. Here, we describe the role in T cell apoptosis of P2X1, a nonselective cation channel activated by ATP. P2X1 molecules are up-regulated in thymocytes during dexamethasone-induced apoptosis, and antagonists to these receptors protect thymocytes from cell death. Moreover, P2X1 mRNA and protein levels increase in thymocytes induced to die in vivo by the superantigen staphylococcal enterotoxin B. In contrast, T cells undergoing apoptosis in the periphery do not express P2X1. The demonstration that P2X1 ion channels play a role in the apoptosis of thymocytes but not peripheral T cells illustrates a novel mechanism contributing to thymocyte cell death and opens new possibilities for investigating clonal deletion in the thymus." @default.
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- W2014350022 date "1996-09-01" @default.
- W2014350022 modified "2023-10-18" @default.
- W2014350022 title "The Involvement of an ATP-Gated Ion Channel, P2X1, in Thymocyte Apoptosis" @default.
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- W2014350022 doi "https://doi.org/10.1016/s1074-7613(00)80322-2" @default.
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