Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014350033> ?p ?o ?g. }
- W2014350033 abstract "Macrophages are important for maintaining intestinal immune homeostasis. Here, we show that PPARβ/δ (peroxisome proliferator-activated receptor β/δ) directly regulates CD300a in macrophages that express the immunoreceptor tyrosine based-inhibitory motif (ITIM)-containing receptor. In mice lacking CD300a, high-fat diet (HFD) causes chronic intestinal inflammation with low numbers of intestinal lymph capillaries and dramatically expanded mesenteric lymph nodes. As a result, these mice exhibit triglyceride malabsorption and reduced body weight gain on HFD. Peritoneal macrophages from Cd300a-/- mice on HFD are classically M1 activated. Activation of toll-like receptor 4 (TLR4)/MyD88 signaling by lipopolysaccharide (LPS) results in prolonged IL-6 secretion in Cd300a-/- macrophages. Bone marrow transplantation confirmed that the phenotype originates from CD300a deficiency in leucocytes. These results identify CD300a-mediated inhibitory signaling in macrophages as a critical regulator of intestinal immune homeostasis." @default.
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- W2014350033 date "2014-06-24" @default.
- W2014350033 modified "2023-10-16" @default.
- W2014350033 title "PPARβ/δ activation of CD300a controls intestinal immunity" @default.
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- W2014350033 doi "https://doi.org/10.1038/srep05412" @default.
- W2014350033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067692" @default.
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