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- W2014356544 abstract "The effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide), a calmodulin antagonist, on the structure of calmodulin was studied with 400 MHz H-NMR. W-7 affected the calcium-induced conformational change of calmodulin in several resonances. One resonant peak was assigned to the His-107 H2 proton. The other peaks were seen in the area of the methionine methyl group (around 2 ppm) and the high-field methyl group (0-1 ppm), these peaks cannot be assigned. The modifying effect of W-7 on the methyl-group resonances of calmodulin fully bound with Ca2+ was similar to that of trifluoperazine. However, the effect on the His-107 H2 proton was unique to W-7." @default.
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- W2014356544 date "1986-09-01" @default.
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- W2014356544 title "1H-NMR studies of calmodulin: the effect of W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide) and Ca2+ on conformational changes of calmodulin" @default.
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- W2014356544 doi "https://doi.org/10.1016/0167-4838(86)90203-7" @default.
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