FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014356632> ?p ?o ?g. }

• W2014356632 endingPage "787" @default.
• W2014356632 startingPage "777" @default.
• W2014356632 abstract "2-Mercaptobenzimidazole (2-MBI), a rubber antioxidant, is known to exhibit potent antithyroid toxicity in rats and is a candidate as an environmental endocrine disrupter. 2-Mercaptomethylbenzimidazoles (a 1:1 mixture of 4-methyl and 5-methyl isomers, MMBIs), are also employed industrially as rubber antioxidants and are suspected to exert antithyroid toxicity such as 2-MBI. In this investigation, acute and subacute oral toxicity studies of MMBIs in Wistar rats were conducted. The clinical signs of acute oral toxicity were observed including decreased spontaneous movement, a paralytic gait, salivation and lacrimation, and adoption of prone and lateral positions. The LD50 was estimated to be 330 mg/kg. In the subacute oral toxicity study, male and female rats were treated with MMBIs by gavage at doses of 0 (corn oil), 4, 20 and 100 mg/kg for 28 consecutive days followed by a 2-week recovery period for the control and highest dose groups. Body weight and food consumption, clinical signs, organ weights, clinical biochemistry and haematological parameters including clotting times and micronuclei induction in bone marrow erythropoeitic cells, and histopathology were examined. Relative organ weights of lung, liver and kidney, and serum cholesterol and phospholipid significantly increased in male rats treated with MMBIs at doses of 20 and 100 mg/kg. Male rats administered 100 mg/kg MMBIs exhibited a 1.8-fold increase in thyroid weight associated with histopathological changes but not altered serum thyroid hormone levels. Female rats administered 100 mg MMBIs/kg exhibited significant increases of liver and kidney but not thyroid weights, and serum cholesterol level. The antithyroid toxicity of MMBIs in rats was estimated to be one-tenth that of 2-MBI. No-observed-effect levels for male and female rats were found to be 4 and 20 mg/kg, respectively, in this subacute oral toxicity study." @default.
• W2014356632 created "2016-06-24" @default.
• W2014356632 creator A5006768230 @default.
• W2014356632 creator A5010967300 @default.
• W2014356632 creator A5016765346 @default.
• W2014356632 creator A5023805155 @default.
• W2014356632 creator A5029765609 @default.
• W2014356632 creator A5030149147 @default.
• W2014356632 creator A5032709542 @default.
• W2014356632 creator A5040021599 @default.
• W2014356632 creator A5040172517 @default.
• W2014356632 creator A5041515550 @default.
• W2014356632 creator A5048322272 @default.
• W2014356632 creator A5049851204 @default.
• W2014356632 creator A5060595394 @default.
• W2014356632 creator A5063381098 @default.
• W2014356632 creator A5070698304 @default.
• W2014356632 creator A5077885174 @default.
• W2014356632 creator A5091071220 @default.
• W2014356632 date "1999-07-01" @default.
• W2014356632 modified "2023-10-18" @default.
• W2014356632 title "Toxicity Study of a Rubber Antioxidant, Mixture of 2-Mercaptomethylbenzimidazoles, by Repeated Oral Administration to Rats" @default.
• W2014356632 cites W1965775175 @default.
• W2014356632 cites W1973713220 @default.
• W2014356632 cites W1974761859 @default.
• W2014356632 cites W2007672028 @default.
• W2014356632 cites W2011279163 @default.
• W2014356632 cites W2018245407 @default.
• W2014356632 cites W2037098192 @default.
• W2014356632 cites W2042464457 @default.
• W2014356632 cites W2045583319 @default.
• W2014356632 cites W2069709516 @default.
• W2014356632 cites W2080852992 @default.
• W2014356632 cites W2082188588 @default.
• W2014356632 cites W2111621105 @default.
• W2014356632 cites W2132798984 @default.
• W2014356632 cites W2164467062 @default.
• W2014356632 cites W2185120011 @default.
• W2014356632 doi "https://doi.org/10.1016/s0278-6915(99)00058-7" @default.
• W2014356632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10496380" @default.
• W2014356632 hasPublicationYear "1999" @default.
• W2014356632 type Work @default.
• W2014356632 sameAs 2014356632 @default.
• W2014356632 citedByCount "12" @default.
• W2014356632 countsByYear W20143566322013 @default.
• W2014356632 countsByYear W20143566322017 @default.
• W2014356632 countsByYear W20143566322020 @default.
• W2014356632 countsByYear W20143566322021 @default.
• W2014356632 countsByYear W20143566322022 @default.
• W2014356632 countsByYear W20143566322023 @default.
• W2014356632 crossrefType "journal-article" @default.
• W2014356632 hasAuthorship W2014356632A5006768230 @default.
• W2014356632 hasAuthorship W2014356632A5010967300 @default.
• W2014356632 hasAuthorship W2014356632A5016765346 @default.
• W2014356632 hasAuthorship W2014356632A5023805155 @default.
• W2014356632 hasAuthorship W2014356632A5029765609 @default.
• W2014356632 hasAuthorship W2014356632A5030149147 @default.
• W2014356632 hasAuthorship W2014356632A5032709542 @default.
• W2014356632 hasAuthorship W2014356632A5040021599 @default.
• W2014356632 hasAuthorship W2014356632A5040172517 @default.
• W2014356632 hasAuthorship W2014356632A5041515550 @default.
• W2014356632 hasAuthorship W2014356632A5048322272 @default.
• W2014356632 hasAuthorship W2014356632A5049851204 @default.
• W2014356632 hasAuthorship W2014356632A5060595394 @default.
• W2014356632 hasAuthorship W2014356632A5063381098 @default.
• W2014356632 hasAuthorship W2014356632A5070698304 @default.
• W2014356632 hasAuthorship W2014356632A5077885174 @default.
• W2014356632 hasAuthorship W2014356632A5091071220 @default.
• W2014356632 hasConcept C126322002 @default.
• W2014356632 hasConcept C134018914 @default.
• W2014356632 hasConcept C142724271 @default.
• W2014356632 hasConcept C185592680 @default.
• W2014356632 hasConcept C2777056448 @default.
• W2014356632 hasConcept C2778004101 @default.
• W2014356632 hasConcept C2778206080 @default.
• W2014356632 hasConcept C2780091579 @default.
• W2014356632 hasConcept C29730261 @default.
• W2014356632 hasConcept C42407357 @default.
• W2014356632 hasConcept C526584372 @default.
• W2014356632 hasConcept C544855455 @default.
• W2014356632 hasConcept C55493867 @default.
• W2014356632 hasConcept C71924100 @default.
• W2014356632 hasConcept C98274493 @default.
• W2014356632 hasConceptScore W2014356632C126322002 @default.
• W2014356632 hasConceptScore W2014356632C134018914 @default.
• W2014356632 hasConceptScore W2014356632C142724271 @default.
• W2014356632 hasConceptScore W2014356632C185592680 @default.
• W2014356632 hasConceptScore W2014356632C2777056448 @default.
• W2014356632 hasConceptScore W2014356632C2778004101 @default.
• W2014356632 hasConceptScore W2014356632C2778206080 @default.
• W2014356632 hasConceptScore W2014356632C2780091579 @default.
• W2014356632 hasConceptScore W2014356632C29730261 @default.
• W2014356632 hasConceptScore W2014356632C42407357 @default.
• W2014356632 hasConceptScore W2014356632C526584372 @default.
• W2014356632 hasConceptScore W2014356632C544855455 @default.
• W2014356632 hasConceptScore W2014356632C55493867 @default.
• W2014356632 hasConceptScore W2014356632C71924100 @default.
• W2014356632 hasConceptScore W2014356632C98274493 @default.

• next