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• W2014357192 endingPage "206" @default.
• W2014357192 startingPage "197" @default.
• W2014357192 abstract "Insulin has long been recognized as a key regulator of energy homeostasis via its actions at the level of the brain, but in addition, plays a role in regulating neural control of reproduction. In this review, we consider and compare evidence from animal models demonstrating a role for insulin for physiological control of reproduction by effects on GnRH/LH secretion. We also review the role that insulin plays in prenatal programming of adult reproduction, and consider specific candidate neurons in the adult hypothalamus by which insulin may act to regulate reproductive function. Finally, we review clinical evidence of the role that insulin may play in adult human fertility and reproductive disorders. Overall, while insulin appears to have a significant impact on reproductive neuroendocrine function, there are many unanswered questions regarding its precise sites and mechanisms of action, and their impact on developing and adult reproductive neuroendocrine function." @default.
• W2014357192 created "2016-06-24" @default.
• W2014357192 creator A5017075448 @default.
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• W2014357192 creator A5078537040 @default.
• W2014357192 date "2014-06-01" @default.
• W2014357192 modified "2023-10-16" @default.
• W2014357192 title "Insulin: Its role in the central control of reproduction" @default.
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