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- W2014361418 endingPage "691" @default.
- W2014361418 startingPage "677" @default.
- W2014361418 abstract "Advances in high-throughput screening methodologies, biological reagents and in silico techniques relating to cytochrome p450 (CYP)-mediated drug-drug interactions have led to reduced clinical attrition rates and to the development of safer therapeutics. Greater understanding of the impact of genetic variability and CYP induction on drug interactions, particularly for low therapeutic index drugs, has facilitated improved clinical study design. This review outlines recent developments using in vitro and in silico technologies to study CYP-mediated drug interactions and describes how those tools have been combined to drive improved candidate selection and in vivo predictions early in the drug discovery process." @default.
- W2014361418 created "2016-06-24" @default.
- W2014361418 creator A5010400710 @default.
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- W2014361418 creator A5050680836 @default.
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- W2014361418 date "2006-12-01" @default.
- W2014361418 modified "2023-10-14" @default.
- W2014361418 title "Advances in predicting CYP-mediated drug interactions in the drug discovery setting" @default.
- W2014361418 cites W1557050709 @default.
- W2014361418 cites W1581167824 @default.
- W2014361418 cites W1587549092 @default.
- W2014361418 cites W177796355 @default.
- W2014361418 cites W1895993106 @default.
- W2014361418 cites W1898420966 @default.
- W2014361418 cites W1964593962 @default.
- W2014361418 cites W1965824042 @default.
- W2014361418 cites W1967295403 @default.
- W2014361418 cites W1967782384 @default.
- W2014361418 cites W1975206909 @default.
- W2014361418 cites W1975691556 @default.
- W2014361418 cites W1977804940 @default.
- W2014361418 cites W1978400865 @default.
- W2014361418 cites W1980800109 @default.
- W2014361418 cites W1981873124 @default.
- W2014361418 cites W1982172626 @default.
- W2014361418 cites W1992475241 @default.
- W2014361418 cites W1996202645 @default.
- W2014361418 cites W1996841450 @default.
- W2014361418 cites W1997014027 @default.
- W2014361418 cites W1997271604 @default.
- W2014361418 cites W1998622278 @default.
- W2014361418 cites W2009649574 @default.
- W2014361418 cites W2011622545 @default.
- W2014361418 cites W2016359652 @default.
- W2014361418 cites W2016915339 @default.
- W2014361418 cites W2020638757 @default.
- W2014361418 cites W2023951398 @default.
- W2014361418 cites W2024092139 @default.
- W2014361418 cites W2028286651 @default.
- W2014361418 cites W2029327304 @default.
- W2014361418 cites W2030926866 @default.
- W2014361418 cites W2031011202 @default.
- W2014361418 cites W2032390387 @default.
- W2014361418 cites W2035168432 @default.
- W2014361418 cites W2036728940 @default.
- W2014361418 cites W2037906595 @default.
- W2014361418 cites W2038480923 @default.
- W2014361418 cites W2044793333 @default.
- W2014361418 cites W2045043540 @default.
- W2014361418 cites W2047195343 @default.
- W2014361418 cites W2048746773 @default.
- W2014361418 cites W2049271629 @default.
- W2014361418 cites W2049958654 @default.
- W2014361418 cites W2054525309 @default.
- W2014361418 cites W2055005853 @default.
- W2014361418 cites W2060442875 @default.
- W2014361418 cites W2061108237 @default.
- W2014361418 cites W2061152607 @default.
- W2014361418 cites W2065228188 @default.
- W2014361418 cites W2065336383 @default.
- W2014361418 cites W2068854073 @default.
- W2014361418 cites W2068983656 @default.
- W2014361418 cites W2069002111 @default.
- W2014361418 cites W2070098436 @default.
- W2014361418 cites W2070424612 @default.
- W2014361418 cites W2075870841 @default.
- W2014361418 cites W2080972628 @default.
- W2014361418 cites W2082428499 @default.
- W2014361418 cites W2083791591 @default.
- W2014361418 cites W2086187432 @default.
- W2014361418 cites W2088916380 @default.
- W2014361418 cites W2089423429 @default.
- W2014361418 cites W2089796665 @default.
- W2014361418 cites W2093006770 @default.
- W2014361418 cites W2093703284 @default.
- W2014361418 cites W2095117565 @default.
- W2014361418 cites W2095836707 @default.
- W2014361418 cites W2098154721 @default.
- W2014361418 cites W2100117732 @default.
- W2014361418 cites W2104775574 @default.
- W2014361418 cites W2105587896 @default.
- W2014361418 cites W2109453128 @default.
- W2014361418 cites W2114464891 @default.
- W2014361418 cites W2116855266 @default.
- W2014361418 cites W2117543172 @default.
- W2014361418 cites W2119951672 @default.
- W2014361418 cites W2120467119 @default.
- W2014361418 cites W2120681931 @default.
- W2014361418 cites W2120906462 @default.
- W2014361418 cites W2121484553 @default.
- W2014361418 cites W2122103602 @default.
- W2014361418 cites W2124596533 @default.
- W2014361418 cites W2129121859 @default.
- W2014361418 cites W2129496553 @default.
- W2014361418 cites W2131840742 @default.
- W2014361418 cites W2134662597 @default.
- W2014361418 cites W2142445277 @default.