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• W2014365220 startingPage "10274" @default.
• W2014365220 abstract "Compounds incorporating the triphenylmethyl motif constitute an emerging family of potent anticancer agents. Although several small molecules containing this pharmacophore have now been identified, the mechanism of cell death induction for some of these compounds is unknown. In an effort to define their mechanism of action, and to distinguish subtypes within the group of compounds containing the triphenylmethyl moiety, we have created novel triphenylmethyl-containing small molecules and have evaluated them in a battery of biological assays. Here we show that several phosphonate and phosphonochloridates possessing the triphenylmethyl motif potently induce death of multiple cancer cell lines in culture. Further assays evaluating the ability to cause cell cycle arrest, inhibit tubulin polymerization, dissociate mitochondrial-bound hexokinase in cancer cells, and inhibit calcium-dependent potassium ion channels indicate that triphenylmethyl-containing compounds can be placed into at least four distinct categories, each with a different mechanism of action." @default.
• W2014365220 created "2016-06-24" @default.
• W2014365220 creator A5027996458 @default.
• W2014365220 creator A5043269944 @default.
• W2014365220 creator A5048019322 @default.
• W2014365220 date "2008-07-09" @default.
• W2014365220 modified "2023-09-26" @default.
• W2014365220 title "The Complex Role of the Triphenylmethyl Motif in Anticancer Compounds" @default.
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• W2014365220 doi "https://doi.org/10.1021/ja8020999" @default.
• W2014365220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18611022" @default.
• W2014365220 hasPublicationYear "2008" @default.
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