FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014365512> ?p ?o ?g. }

• W2014365512 abstract "Partially purified extracts from neuroblastoma X glioma hybrid cells 108CC15 inhibit, like opioids, the prostaglandin E1-evoked formation of cyclic AMP in a dose-dependent manner in the same hybrid cells. The inhibition is prevented by the opioid antagonist naloxone. In addition, the same extract competes with [3H]naloxone and [3H]Leu-enkephalin for binding to opioid receptors of hybrid cell membranes and to a specific antiserum, respectively. The opioid activity in the extracts is destroyed by carboxypeptidase A and leucine aminopeptidase, but not by trypsin. Further purification of the extracts by HPLC, TLC, or high-voltage paper electrophoresis reveals in each case two active fractions which behave like Met- and Leu-enkephalin. The Met-enkephalin-like, but not the Leu-enkephalin-like, fraction is inactivated by treatment with BrCN. Dimethylaminonaphtylsulfonyl (dansyl) derivatives of Met- and Leu-enkephalin correspond to [3H]dansyl derivatives of Met-like substances from hybrid cells. Three to four times as much Met-enkephalin-like as Leu-enkephalin-like material is present in the extract. The overall concentration of opioid peptides in the hybrid cells varies between 0.03 and 1.0 pmol Leu-enkephalin equivalents per mg protein. The amount of opioids in the hybrid cells is strongly dependent on the cell density. The findings suggest that neuroblastoma X glioma hybrid cells contain opioid peptides that are very similar, if not identical, to Met- and Leu-enkephalin. Opioid activity can also be detected in other neuronal cell lines and even in glioma cells." @default.
• W2014365512 created "2016-06-24" @default.
• W2014365512 creator A5020958512 @default.
• W2014365512 creator A5064842799 @default.
• W2014365512 creator A5090177774 @default.
• W2014365512 date "1982-07-01" @default.
• W2014365512 modified "2023-09-25" @default.
• W2014365512 title "Neuroblastoma × Glioma Hybrid Cells Synthesize Enkephalin-Like Opioid Peptides" @default.
• W2014365512 cites W1093746230 @default.
• W2014365512 cites W1496570301 @default.
• W2014365512 cites W1513633721 @default.
• W2014365512 cites W1606256000 @default.
• W2014365512 cites W1775749144 @default.
• W2014365512 cites W1930237192 @default.
• W2014365512 cites W1964733226 @default.
• W2014365512 cites W1965632205 @default.
• W2014365512 cites W1965692713 @default.
• W2014365512 cites W1968315737 @default.
• W2014365512 cites W1981167228 @default.
• W2014365512 cites W1985113808 @default.
• W2014365512 cites W1995174089 @default.
• W2014365512 cites W1996974572 @default.
• W2014365512 cites W1998118314 @default.
• W2014365512 cites W2003206650 @default.
• W2014365512 cites W2010051841 @default.
• W2014365512 cites W2017509400 @default.
• W2014365512 cites W2023671637 @default.
• W2014365512 cites W2023858395 @default.
• W2014365512 cites W2024067438 @default.
• W2014365512 cites W2025089116 @default.
• W2014365512 cites W2027745203 @default.
• W2014365512 cites W2031297740 @default.
• W2014365512 cites W2032091462 @default.
• W2014365512 cites W2033680879 @default.
• W2014365512 cites W2036455062 @default.
• W2014365512 cites W2044773469 @default.
• W2014365512 cites W2045502732 @default.
• W2014365512 cites W2049325497 @default.
• W2014365512 cites W2049414447 @default.
• W2014365512 cites W2051612811 @default.
• W2014365512 cites W2053243081 @default.
• W2014365512 cites W2053793579 @default.
• W2014365512 cites W2054951528 @default.
• W2014365512 cites W2055560376 @default.
• W2014365512 cites W2059462636 @default.
• W2014365512 cites W2062446444 @default.
• W2014365512 cites W2063156553 @default.
• W2014365512 cites W2073429154 @default.
• W2014365512 cites W2073749796 @default.
• W2014365512 cites W2078594524 @default.
• W2014365512 cites W2081910239 @default.
• W2014365512 cites W2089462923 @default.
• W2014365512 cites W2093091152 @default.
• W2014365512 cites W2113808519 @default.
• W2014365512 cites W2181089794 @default.
• W2014365512 cites W2325915379 @default.
• W2014365512 cites W2339523281 @default.
• W2014365512 cites W2001244070 @default.
• W2014365512 doi "https://doi.org/10.1111/j.1471-4159.1982.tb04701.x" @default.
• W2014365512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6283022" @default.
• W2014365512 hasPublicationYear "1982" @default.
• W2014365512 type Work @default.
• W2014365512 sameAs 2014365512 @default.
• W2014365512 citedByCount "21" @default.
• W2014365512 crossrefType "journal-article" @default.
• W2014365512 hasAuthorship W2014365512A5020958512 @default.
• W2014365512 hasAuthorship W2014365512A5064842799 @default.
• W2014365512 hasAuthorship W2014365512A5090177774 @default.
• W2014365512 hasConcept C118303440 @default.
• W2014365512 hasConcept C170493617 @default.
• W2014365512 hasConcept C185592680 @default.
• W2014365512 hasConcept C2775962371 @default.
• W2014365512 hasConcept C2776007765 @default.
• W2014365512 hasConcept C2776580952 @default.
• W2014365512 hasConcept C2776715637 @default.
• W2014365512 hasConcept C2777621412 @default.
• W2014365512 hasConcept C2777803847 @default.
• W2014365512 hasConcept C2778750930 @default.
• W2014365512 hasConcept C2779886867 @default.
• W2014365512 hasConcept C2780985610 @default.
• W2014365512 hasConcept C2781063702 @default.
• W2014365512 hasConcept C515207424 @default.
• W2014365512 hasConcept C54355233 @default.
• W2014365512 hasConcept C55493867 @default.
• W2014365512 hasConcept C81885089 @default.
• W2014365512 hasConcept C86803240 @default.
• W2014365512 hasConcept C88016717 @default.
• W2014365512 hasConcept C98274493 @default.
• W2014365512 hasConceptScore W2014365512C118303440 @default.
• W2014365512 hasConceptScore W2014365512C170493617 @default.
• W2014365512 hasConceptScore W2014365512C185592680 @default.
• W2014365512 hasConceptScore W2014365512C2775962371 @default.
• W2014365512 hasConceptScore W2014365512C2776007765 @default.
• W2014365512 hasConceptScore W2014365512C2776580952 @default.
• W2014365512 hasConceptScore W2014365512C2776715637 @default.
• W2014365512 hasConceptScore W2014365512C2777621412 @default.
• W2014365512 hasConceptScore W2014365512C2777803847 @default.
• W2014365512 hasConceptScore W2014365512C2778750930 @default.
• W2014365512 hasConceptScore W2014365512C2779886867 @default.
• W2014365512 hasConceptScore W2014365512C2780985610 @default.

• next