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• W2014366175 abstract "Recent studies in adult and weanling rats show that dietary fat, in close association with circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling food intake and body weight. In the present study, we examined the possibility that a fat-rich diet during pregnancy alters the development of these peptide systems in utero, producing neuronal changes in the offspring that persist postnatally in the absence of the diet and have long-term consequences. The offspring of dams on a high-fat diet (HFD) versus balanced diet (BD), from embryonic day 6 to postnatal day 15 (P15), showed increased expression of orexigenic peptides, galanin, enkephalin, and dynorphin, in the paraventricular nucleus and orexin and melanin-concentrating hormone in the perifornical lateral hypothalamus. The increased density of these peptide-expressing neurons, evident in newborn offspring as well as P15 offspring cross-fostered at birth to dams on the BD, led us to examine events that might be occurring in utero. During gestation, the HFD stimulated the proliferation of neuroepithelial and neuronal precursor cells of the embryonic hypothalamic third ventricle. It also stimulated the proliferation and differentiation of neurons and their migration toward hypothalamic areas where ultimately a greater proportion of the new neurons expressed the orexigenic peptides. This increase in neurogenesis, closely associated with a marked increase in lipids in the blood, may have a role in producing the long-term behavioral and physiological changes observed in offspring after weaning, including an increase in food intake, preference for fat, hyperlipidemia, and higher body weight." @default.
• W2014366175 created "2016-06-24" @default.
• W2014366175 creator A5016800957 @default.
• W2014366175 creator A5028898765 @default.
• W2014366175 creator A5053490489 @default.
• W2014366175 creator A5090507281 @default.
• W2014366175 date "2008-11-12" @default.
• W2014366175 modified "2023-10-12" @default.
• W2014366175 title "Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity" @default.
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• W2014366175 doi "https://doi.org/10.1523/jneurosci.2642-08.2008" @default.
• W2014366175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2752048" @default.
• W2014366175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19005075" @default.
• W2014366175 hasPublicationYear "2008" @default.
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