FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014366893> ?p ?o ?g. }

• W2014366893 endingPage "e33355" @default.
• W2014366893 startingPage "e33355" @default.
• W2014366893 abstract "Background Genetic variability in the regulation of the nitric oxide (NO) pathway may influence hemodynamic changes in pediatric sepsis. We sought to determine whether functional polymorphisms in DDAH2, which metabolizes the NO synthase inhibitor asymmetric dimethylarginine (ADMA), are associated with susceptibility to sepsis, plasma ADMA, distinct hemodynamic states, and vasopressor requirements in pediatric septic shock. Methodology/Principal Findings In a prospective study, blood and buccal swabs were obtained from 82 patients ≤18 years (29 with severe sepsis/septic shock plus 27 febrile and 26 healthy controls). Plasma ADMA was measured using tandem mass spectrometry. DDAH2 gene was partially sequenced to determine the −871 6g/7g insertion/deletion and −449G/C single nucleotide polymorphisms. Shock type (“warm” versus “cold”) was characterized by clinical assessment. The −871 7g allele was more common in septic (17%) then febrile (4%) and healthy (8%) patients, though this was not significant after controlling for sex and race (p = 0.96). ADMA did not differ between −871 6g/7g genotypes. While genotype frequencies also did not vary between groups for the −449G/C SNP (p = 0.75), septic patients with at least one −449G allele had lower ADMA (median, IQR 0.36, 0.30–0.41 µmol/L) than patients with the −449CC genotype (0.55, 0.49–0.64 µmol/L, p = 0.008) and exhibited a higher incidence of “cold” shock (45% versus 0%, p = 0.01). However, after controlling for race, the association with shock type became non-significant (p = 0.32). Neither polymorphism was associated with inotrope score or vasoactive infusion duration. Conclusions/Significance The −449G polymorphism in the DDAH2 gene was associated with both low plasma ADMA and an increased likelihood of presenting with “cold” shock in pediatric sepsis, but not with vasopressor requirement. Race, however, was an important confounder. These results support and justify the need for larger studies in racially homogenous populations to further examine whether genotypic differences in NO metabolism contribute to phenotypic variability in sepsis pathophysiology." @default.
• W2014366893 created "2016-06-24" @default.
• W2014366893 creator A5008800811 @default.
• W2014366893 creator A5039053483 @default.
• W2014366893 creator A5043894861 @default.
• W2014366893 creator A5048932268 @default.
• W2014366893 creator A5084339424 @default.
• W2014366893 creator A5087567621 @default.
• W2014366893 date "2012-03-12" @default.
• W2014366893 modified "2023-10-16" @default.
• W2014366893 title "Pilot Study of the Association of the DDAH2 −449G Polymorphism with Asymmetric Dimethylarginine and Hemodynamic Shock in Pediatric Sepsis" @default.
• W2014366893 cites W1538170740 @default.
• W2014366893 cites W1966641545 @default.
• W2014366893 cites W1966929474 @default.
• W2014366893 cites W1969850821 @default.
• W2014366893 cites W1975187080 @default.
• W2014366893 cites W1984332977 @default.
• W2014366893 cites W2001778442 @default.
• W2014366893 cites W2001837257 @default.
• W2014366893 cites W2002926363 @default.
• W2014366893 cites W2015814983 @default.
• W2014366893 cites W2024147658 @default.
• W2014366893 cites W2031800792 @default.
• W2014366893 cites W2033631367 @default.
• W2014366893 cites W2036140137 @default.
• W2014366893 cites W2036980214 @default.
• W2014366893 cites W2043851240 @default.
• W2014366893 cites W2050405548 @default.
• W2014366893 cites W2060432861 @default.
• W2014366893 cites W2062232972 @default.
• W2014366893 cites W2062434417 @default.
• W2014366893 cites W2070993775 @default.
• W2014366893 cites W2076065477 @default.
• W2014366893 cites W2076355884 @default.
• W2014366893 cites W2076590961 @default.
• W2014366893 cites W2088014341 @default.
• W2014366893 cites W2088553090 @default.
• W2014366893 cites W2106824578 @default.
• W2014366893 cites W2112529329 @default.
• W2014366893 cites W2119177204 @default.
• W2014366893 cites W2119998073 @default.
• W2014366893 cites W2123466824 @default.
• W2014366893 cites W2124718979 @default.
• W2014366893 cites W2126777636 @default.
• W2014366893 cites W2129050578 @default.
• W2014366893 cites W2129171193 @default.
• W2014366893 cites W2138697408 @default.
• W2014366893 cites W2145183598 @default.
• W2014366893 cites W2151554519 @default.
• W2014366893 cites W2154696953 @default.
• W2014366893 cites W2154911803 @default.
• W2014366893 cites W3017100980 @default.
• W2014366893 cites W4252852453 @default.
• W2014366893 doi "https://doi.org/10.1371/journal.pone.0033355" @default.
• W2014366893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3299781" @default.
• W2014366893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22428028" @default.
• W2014366893 hasPublicationYear "2012" @default.
• W2014366893 type Work @default.
• W2014366893 sameAs 2014366893 @default.
• W2014366893 citedByCount "10" @default.
• W2014366893 countsByYear W20143668932013 @default.
• W2014366893 countsByYear W20143668932014 @default.
• W2014366893 countsByYear W20143668932015 @default.
• W2014366893 countsByYear W20143668932016 @default.
• W2014366893 countsByYear W20143668932017 @default.
• W2014366893 crossrefType "journal-article" @default.
• W2014366893 hasAuthorship W2014366893A5008800811 @default.
• W2014366893 hasAuthorship W2014366893A5039053483 @default.
• W2014366893 hasAuthorship W2014366893A5043894861 @default.
• W2014366893 hasAuthorship W2014366893A5048932268 @default.
• W2014366893 hasAuthorship W2014366893A5084339424 @default.
• W2014366893 hasAuthorship W2014366893A5087567621 @default.
• W2014366893 hasBestOaLocation W20143668931 @default.
• W2014366893 hasConcept C104317684 @default.
• W2014366893 hasConcept C126322002 @default.
• W2014366893 hasConcept C134018914 @default.
• W2014366893 hasConcept C135763542 @default.
• W2014366893 hasConcept C153209595 @default.
• W2014366893 hasConcept C178853913 @default.
• W2014366893 hasConcept C2777468819 @default.
• W2014366893 hasConcept C2777628635 @default.
• W2014366893 hasConcept C2778384902 @default.
• W2014366893 hasConcept C2779877776 @default.
• W2014366893 hasConcept C515207424 @default.
• W2014366893 hasConcept C54355233 @default.
• W2014366893 hasConcept C71924100 @default.
• W2014366893 hasConcept C86803240 @default.
• W2014366893 hasConcept C90924648 @default.
• W2014366893 hasConceptScore W2014366893C104317684 @default.
• W2014366893 hasConceptScore W2014366893C126322002 @default.
• W2014366893 hasConceptScore W2014366893C134018914 @default.
• W2014366893 hasConceptScore W2014366893C135763542 @default.
• W2014366893 hasConceptScore W2014366893C153209595 @default.
• W2014366893 hasConceptScore W2014366893C178853913 @default.
• W2014366893 hasConceptScore W2014366893C2777468819 @default.
• W2014366893 hasConceptScore W2014366893C2777628635 @default.
• W2014366893 hasConceptScore W2014366893C2778384902 @default.
• W2014366893 hasConceptScore W2014366893C2779877776 @default.

• next