Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014367159> ?p ?o ?g. }
- W2014367159 endingPage "491" @default.
- W2014367159 startingPage "479" @default.
- W2014367159 abstract "Heme oxygenase (HO), the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and bilirubin, has recently received overwhelming research attention. To date three mammalian HO isozymes have been identified, and the only inducible form is HO-1 while HO-2 and HO-3 are constitutively expressed. Advances in unveiling signal transduction network indicate that a battery of redox-sensitive transcription factors, such as activator protein-1 (AP-1), nuclear factor-kappa B (NF-<TEX>${kappa}B$</TEX>) and nuclear factor E2-related factor-2 (Nrf2), and their upstream kinases including mitogen-activated protein kinases play an important regulatory role in HO-1 gene induction. The products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli. In this context, it is interesting to note that induction of HO-1 expression contributes to protection against liver damage induced by several chemical compounds such as acetaminophen, carbon tetrachloride and heavy metals, suggesting HO-1 induction as an important cellular endeavor for hepatoprotection. The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect against chemically-induced liver injury as well as hepatocarcinogenesis." @default.
- W2014367159 created "2016-06-24" @default.
- W2014367159 creator A5035346033 @default.
- W2014367159 creator A5042416221 @default.
- W2014367159 date "2006-09-30" @default.
- W2014367159 modified "2023-10-12" @default.
- W2014367159 title "Heme Oxygenase-1 as a Potential Therapeutic Target for Hepatoprotection" @default.
- W2014367159 cites W1521068719 @default.
- W2014367159 cites W1551093971 @default.
- W2014367159 cites W1595398256 @default.
- W2014367159 cites W1964111488 @default.
- W2014367159 cites W1965093955 @default.
- W2014367159 cites W1966582616 @default.
- W2014367159 cites W1969599148 @default.
- W2014367159 cites W1973016992 @default.
- W2014367159 cites W1973272666 @default.
- W2014367159 cites W1977427732 @default.
- W2014367159 cites W1978589242 @default.
- W2014367159 cites W1979611363 @default.
- W2014367159 cites W1980360532 @default.
- W2014367159 cites W1984428820 @default.
- W2014367159 cites W1985863048 @default.
- W2014367159 cites W1987777210 @default.
- W2014367159 cites W1988698410 @default.
- W2014367159 cites W1989889461 @default.
- W2014367159 cites W1990472260 @default.
- W2014367159 cites W1991303210 @default.
- W2014367159 cites W1991631628 @default.
- W2014367159 cites W1991844778 @default.
- W2014367159 cites W1994197049 @default.
- W2014367159 cites W1996805006 @default.
- W2014367159 cites W1997325365 @default.
- W2014367159 cites W2000874885 @default.
- W2014367159 cites W2002154317 @default.
- W2014367159 cites W2002652481 @default.
- W2014367159 cites W2004491334 @default.
- W2014367159 cites W2006161003 @default.
- W2014367159 cites W2006279277 @default.
- W2014367159 cites W2006733242 @default.
- W2014367159 cites W2007921246 @default.
- W2014367159 cites W2009800129 @default.
- W2014367159 cites W2013150301 @default.
- W2014367159 cites W2014654222 @default.
- W2014367159 cites W2014806005 @default.
- W2014367159 cites W2015471917 @default.
- W2014367159 cites W2016603646 @default.
- W2014367159 cites W2016727102 @default.
- W2014367159 cites W2018123263 @default.
- W2014367159 cites W2018474491 @default.
- W2014367159 cites W2022847122 @default.
- W2014367159 cites W2023977270 @default.
- W2014367159 cites W2028021793 @default.
- W2014367159 cites W2033083444 @default.
- W2014367159 cites W2033635345 @default.
- W2014367159 cites W2036224418 @default.
- W2014367159 cites W2036729366 @default.
- W2014367159 cites W2037914723 @default.
- W2014367159 cites W2038136238 @default.
- W2014367159 cites W2038500334 @default.
- W2014367159 cites W2039590813 @default.
- W2014367159 cites W2046273424 @default.
- W2014367159 cites W2047253953 @default.
- W2014367159 cites W2047923433 @default.
- W2014367159 cites W2050971607 @default.
- W2014367159 cites W2052232849 @default.
- W2014367159 cites W2054056570 @default.
- W2014367159 cites W2056523101 @default.
- W2014367159 cites W2056916650 @default.
- W2014367159 cites W2060211824 @default.
- W2014367159 cites W2062203763 @default.
- W2014367159 cites W2065190343 @default.
- W2014367159 cites W2065284764 @default.
- W2014367159 cites W2066033513 @default.
- W2014367159 cites W2066241876 @default.
- W2014367159 cites W2066484244 @default.
- W2014367159 cites W2066684838 @default.
- W2014367159 cites W2067346748 @default.
- W2014367159 cites W2067816697 @default.
- W2014367159 cites W2069419508 @default.
- W2014367159 cites W2072256632 @default.
- W2014367159 cites W2072353087 @default.
- W2014367159 cites W2075255010 @default.
- W2014367159 cites W2076494277 @default.
- W2014367159 cites W208076477 @default.
- W2014367159 cites W2081093085 @default.
- W2014367159 cites W2081223652 @default.
- W2014367159 cites W2081497033 @default.
- W2014367159 cites W2082942431 @default.
- W2014367159 cites W2089744076 @default.
- W2014367159 cites W2094102606 @default.
- W2014367159 cites W2094401899 @default.
- W2014367159 cites W2094470927 @default.
- W2014367159 cites W2095285639 @default.
- W2014367159 cites W2095364552 @default.
- W2014367159 cites W2097498628 @default.
- W2014367159 cites W2099244520 @default.
- W2014367159 cites W2113054810 @default.
- W2014367159 cites W2114135209 @default.