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- W2014368135 abstract "In secondary prevention of stroke, aspirin has been hard to beat, because of its well-documented effect, small risk of serious side-effects, and minimum costs. 1 Antithrombotic Trialists' CollaborationCollaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ. 2000; 324: 71-86 Crossref Google Scholar However, the effect is small—only about a quarter of new vascular events are prevented, three-quarters are not. Of other antiplatelet drugs, the effect of dipyridamole alone is even more modest, whereas clopidogrel is only marginally better than aspirin at considerably higher costs. 1 Antithrombotic Trialists' CollaborationCollaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ. 2000; 324: 71-86 Crossref Google Scholar , 2 De Schryver E Algra A van Gijn J Dipyridamole for preventing stroke and other vascular events in patients with vascular disease. Cochrane Database Syst Rev. 2006; 2 (CD001820) PubMed Google Scholar , 3 CAPRIE Steering CommitteeA randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet. 1996; 348: 1329-1339 Summary Full Text Full Text PDF PubMed Scopus (6083) Google Scholar Can we do better? Today's Lancet features the results of ESPRIT, a randomised trial on the combination of aspirin and dipyridamole versus aspirin alone in 2739 patients with transient ischaemic attack and ischaemic stroke. 4 ESPRIT Study GroupAspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet. 2006; 367: 1665-1673 Summary Full Text Full Text PDF PubMed Scopus (915) Google Scholar Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trialThe ESPRIT results, combined with the results of previous trials, provide sufficient evidence to prefer the combination regimen of aspirin plus dipyridamole over aspirin alone as antithrombotic therapy after cerebral ischaemia of arterial origin. Full-Text PDF" @default.
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- W2014368135 date "2006-05-01" @default.
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- W2014368135 title "Dipyridamole with aspirin for secondary stroke prevention" @default.
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- W2014368135 doi "https://doi.org/10.1016/s0140-6736(06)68711-4" @default.
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