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• W2014369670 abstract "Methotrexate analogues, in which an additional nitrogen atom is inserted between the phenyl ring and the carbonyl group of the side chain, were prepared by photochemical methods. The compounds were less inhibitory toward dihydrofolate reductase and thymidylate synthetase derived from Lactobacillus casei than was methotrexate. They were also less cytotoxic against human lymphoblastic leukemia cells (CCRF-CEM). In vivo against L-1210 leukemia in mice, the aza homologue of methotrexate showed significant antitumor activity (%ILS = 55%) compared to methotrexate (%ILS = 88%)." @default.
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• W2014369670 date "1979-07-01" @default.
• W2014369670 modified "2023-10-14" @default.
• W2014369670 title "Methotrexate analogs. 12. Synthesis and biological properties of some aza homologs" @default.
• W2014369670 doi "https://doi.org/10.1021/jm00193a022" @default.
• W2014369670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/109616" @default.
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