FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014369941> ?p ?o ?g. }

• W2014369941 endingPage "1232" @default.
• W2014369941 startingPage "1225" @default.
• W2014369941 abstract "Chromium was proposed to be an essential element over 50 y ago and was shown to have therapeutic potential in treating the symptoms of type 2 diabetes; however, its mechanism of action at a molecular level is unknown. One chromium-binding biomolecule, low-molecular weight chromium-binding substance (LMWCr or chromodulin), has been found to be biologically active in in vitro assays and proposed as a potential candidate for the in vivo biologically active form of chromium. Characterization of the organic component of LMWCr has proven difficult. Treating bovine LMWCr with trifluoroacetic acid followed by purification on a graphite powder micro-column generates a heptapeptide fragment of LMWCr. The peptide sequence of the fragment was analyzed by MS and tandem MS (MS/MS and MS/MS/MS) using collision-induced dissociation and post-source decay. Two candidate sequences, pEEEEGDD and pEEEGEDD (where pE is pyroglutamate), were identified from the MS/MS experiments; additional tandem MS suggests the sequence is pEEEEGDD. The N-terminal glutamate residues explain the inability to sequence LMWCr by the Edman method. Langmuir isotherms and Hill plots were used to analyze the binding constants of chromic ions to synthetic peptides similar in composition to apoLMWCr. The sequence pEEEEGDD was found to bind 4 chromic ions per peptide with nearly identical cooperativity and binding constants to those of apoLMWCr. This work should lead to further studies elucidating or eliminating a potential role for LMWCr in treating the symptoms of type 2 diabetes and other conditions resulting from improper carbohydrate and lipid metabolism." @default.
• W2014369941 created "2016-06-24" @default.
• W2014369941 creator A5001225704 @default.
• W2014369941 creator A5010708205 @default.
• W2014369941 creator A5018920999 @default.
• W2014369941 creator A5037986561 @default.
• W2014369941 creator A5054228973 @default.
• W2014369941 creator A5090755424 @default.
• W2014369941 date "2011-07-01" @default.
• W2014369941 modified "2023-10-11" @default.
• W2014369941 title "Characterization of the Organic Component of Low-Molecular-Weight Chromium-Binding Substance and Its Binding of Chromium" @default.
• W2014369941 cites W1495926848 @default.
• W2014369941 cites W1820823138 @default.
• W2014369941 cites W1929296596 @default.
• W2014369941 cites W1948540585 @default.
• W2014369941 cites W1966848687 @default.
• W2014369941 cites W1968808097 @default.
• W2014369941 cites W1972656394 @default.
• W2014369941 cites W1973666532 @default.
• W2014369941 cites W1974565443 @default.
• W2014369941 cites W1977236174 @default.
• W2014369941 cites W1989947125 @default.
• W2014369941 cites W1999817657 @default.
• W2014369941 cites W2003907618 @default.
• W2014369941 cites W2016031823 @default.
• W2014369941 cites W2016968987 @default.
• W2014369941 cites W2024067674 @default.
• W2014369941 cites W2024681988 @default.
• W2014369941 cites W2028874527 @default.
• W2014369941 cites W2037561129 @default.
• W2014369941 cites W2042656746 @default.
• W2014369941 cites W2048859474 @default.
• W2014369941 cites W2066868909 @default.
• W2014369941 cites W2067160937 @default.
• W2014369941 cites W2070707407 @default.
• W2014369941 cites W2077205477 @default.
• W2014369941 cites W2084198435 @default.
• W2014369941 cites W2086173326 @default.
• W2014369941 cites W2092927679 @default.
• W2014369941 cites W2124831173 @default.
• W2014369941 cites W2135628848 @default.
• W2014369941 cites W2142101386 @default.
• W2014369941 cites W2154382681 @default.
• W2014369941 cites W597306341 @default.
• W2014369941 doi "https://doi.org/10.3945/jn.111.139147" @default.
• W2014369941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3113288" @default.
• W2014369941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21593351" @default.
• W2014369941 hasPublicationYear "2011" @default.
• W2014369941 type Work @default.
• W2014369941 sameAs 2014369941 @default.
• W2014369941 citedByCount "41" @default.
• W2014369941 countsByYear W20143699412012 @default.
• W2014369941 countsByYear W20143699412013 @default.
• W2014369941 countsByYear W20143699412014 @default.
• W2014369941 countsByYear W20143699412015 @default.
• W2014369941 countsByYear W20143699412016 @default.
• W2014369941 countsByYear W20143699412017 @default.
• W2014369941 countsByYear W20143699412018 @default.
• W2014369941 countsByYear W20143699412019 @default.
• W2014369941 countsByYear W20143699412020 @default.
• W2014369941 countsByYear W20143699412021 @default.
• W2014369941 countsByYear W20143699412022 @default.
• W2014369941 countsByYear W20143699412023 @default.
• W2014369941 crossrefType "journal-article" @default.
• W2014369941 hasAuthorship W2014369941A5001225704 @default.
• W2014369941 hasAuthorship W2014369941A5010708205 @default.
• W2014369941 hasAuthorship W2014369941A5018920999 @default.
• W2014369941 hasAuthorship W2014369941A5037986561 @default.
• W2014369941 hasAuthorship W2014369941A5054228973 @default.
• W2014369941 hasAuthorship W2014369941A5090755424 @default.
• W2014369941 hasBestOaLocation W20143699411 @default.
• W2014369941 hasConcept C178790620 @default.
• W2014369941 hasConcept C185592680 @default.
• W2014369941 hasConcept C2779281246 @default.
• W2014369941 hasConcept C2780112151 @default.
• W2014369941 hasConcept C43617362 @default.
• W2014369941 hasConcept C511782168 @default.
• W2014369941 hasConcept C55493867 @default.
• W2014369941 hasConceptScore W2014369941C178790620 @default.
• W2014369941 hasConceptScore W2014369941C185592680 @default.
• W2014369941 hasConceptScore W2014369941C2779281246 @default.
• W2014369941 hasConceptScore W2014369941C2780112151 @default.
• W2014369941 hasConceptScore W2014369941C43617362 @default.
• W2014369941 hasConceptScore W2014369941C511782168 @default.
• W2014369941 hasConceptScore W2014369941C55493867 @default.
• W2014369941 hasIssue "7" @default.
• W2014369941 hasLocation W20143699411 @default.
• W2014369941 hasLocation W20143699412 @default.
• W2014369941 hasLocation W20143699413 @default.
• W2014369941 hasLocation W20143699414 @default.
• W2014369941 hasOpenAccess W2014369941 @default.
• W2014369941 hasPrimaryLocation W20143699411 @default.
• W2014369941 hasRelatedWork W1975256406 @default.
• W2014369941 hasRelatedWork W1983694554 @default.
• W2014369941 hasRelatedWork W2084260844 @default.
• W2014369941 hasRelatedWork W2091538365 @default.
• W2014369941 hasRelatedWork W2139203759 @default.
• W2014369941 hasRelatedWork W2395908720 @default.

• next