Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014372409> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2014372409 endingPage "1190" @default.
- W2014372409 startingPage "1185" @default.
- W2014372409 abstract "We studied the cellular uptake and retention of daunorubicin (D1) in two human leukemic cell lines (ML1 and K562) and myecloblasts from an untreated patient with acute myelogenous leukemia (AML). The rate of uptake and the steady-state level of D1 were not temperature dependent but increased markedly with increases in the pH of the medium. Also, saturation kinetics were not demonstrable using concentrations of D1 up to 111 microM. Together, these observation suggest a transport mechanism for D1 compatible with passive diffusion. Accumulation of D1 was increased only in cells from the AML patient with addition of sodium azide, whereas drug efflux was not increased significantly in the presence of glucose in MLI or K562 cells. Although the rate of uptake and steady-state levels of D1 were the same in these cells, metabolism and cytotoxicity of D1 differed. Our results indicate that ML1 cells can be used as a pharmacologic model for studying the metabolism and resistance of D1 in vivo." @default.
- W2014372409 created "2016-06-24" @default.
- W2014372409 creator A5063585096 @default.
- W2014372409 creator A5077808671 @default.
- W2014372409 date "1986-04-01" @default.
- W2014372409 modified "2023-10-18" @default.
- W2014372409 title "Comparative uptake, retention and cytotoxicity of daunorubicin by human myeloid cells" @default.
- W2014372409 cites W1536507559 @default.
- W2014372409 cites W1964170758 @default.
- W2014372409 cites W2002967757 @default.
- W2014372409 cites W2012519163 @default.
- W2014372409 cites W2014593961 @default.
- W2014372409 cites W2020893327 @default.
- W2014372409 cites W2022740903 @default.
- W2014372409 cites W2035215935 @default.
- W2014372409 cites W2038177667 @default.
- W2014372409 cites W2038634515 @default.
- W2014372409 cites W2041871820 @default.
- W2014372409 cites W2050619731 @default.
- W2014372409 cites W2051201030 @default.
- W2014372409 cites W2065719839 @default.
- W2014372409 cites W2068293186 @default.
- W2014372409 cites W2092855377 @default.
- W2014372409 cites W2395223411 @default.
- W2014372409 doi "https://doi.org/10.1016/0006-2952(86)90158-9" @default.
- W2014372409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3457568" @default.
- W2014372409 hasPublicationYear "1986" @default.
- W2014372409 type Work @default.
- W2014372409 sameAs 2014372409 @default.
- W2014372409 citedByCount "9" @default.
- W2014372409 crossrefType "journal-article" @default.
- W2014372409 hasAuthorship W2014372409A5063585096 @default.
- W2014372409 hasAuthorship W2014372409A5077808671 @default.
- W2014372409 hasConcept C109316439 @default.
- W2014372409 hasConcept C12554922 @default.
- W2014372409 hasConcept C171122931 @default.
- W2014372409 hasConcept C185592680 @default.
- W2014372409 hasConcept C200082930 @default.
- W2014372409 hasConcept C202751555 @default.
- W2014372409 hasConcept C203014093 @default.
- W2014372409 hasConcept C2778461978 @default.
- W2014372409 hasConcept C2778729363 @default.
- W2014372409 hasConcept C2781021840 @default.
- W2014372409 hasConcept C2781417787 @default.
- W2014372409 hasConcept C502942594 @default.
- W2014372409 hasConcept C54355233 @default.
- W2014372409 hasConcept C55493867 @default.
- W2014372409 hasConcept C62231903 @default.
- W2014372409 hasConcept C81885089 @default.
- W2014372409 hasConcept C86803240 @default.
- W2014372409 hasConcept C98274493 @default.
- W2014372409 hasConceptScore W2014372409C109316439 @default.
- W2014372409 hasConceptScore W2014372409C12554922 @default.
- W2014372409 hasConceptScore W2014372409C171122931 @default.
- W2014372409 hasConceptScore W2014372409C185592680 @default.
- W2014372409 hasConceptScore W2014372409C200082930 @default.
- W2014372409 hasConceptScore W2014372409C202751555 @default.
- W2014372409 hasConceptScore W2014372409C203014093 @default.
- W2014372409 hasConceptScore W2014372409C2778461978 @default.
- W2014372409 hasConceptScore W2014372409C2778729363 @default.
- W2014372409 hasConceptScore W2014372409C2781021840 @default.
- W2014372409 hasConceptScore W2014372409C2781417787 @default.
- W2014372409 hasConceptScore W2014372409C502942594 @default.
- W2014372409 hasConceptScore W2014372409C54355233 @default.
- W2014372409 hasConceptScore W2014372409C55493867 @default.
- W2014372409 hasConceptScore W2014372409C62231903 @default.
- W2014372409 hasConceptScore W2014372409C81885089 @default.
- W2014372409 hasConceptScore W2014372409C86803240 @default.
- W2014372409 hasConceptScore W2014372409C98274493 @default.
- W2014372409 hasIssue "7" @default.
- W2014372409 hasLocation W20143724091 @default.
- W2014372409 hasLocation W20143724092 @default.
- W2014372409 hasOpenAccess W2014372409 @default.
- W2014372409 hasPrimaryLocation W20143724091 @default.
- W2014372409 hasRelatedWork W1974032072 @default.
- W2014372409 hasRelatedWork W1981735895 @default.
- W2014372409 hasRelatedWork W1997787479 @default.
- W2014372409 hasRelatedWork W2014372409 @default.
- W2014372409 hasRelatedWork W2029347230 @default.
- W2014372409 hasRelatedWork W2048313550 @default.
- W2014372409 hasRelatedWork W2093792954 @default.
- W2014372409 hasRelatedWork W2113871094 @default.
- W2014372409 hasRelatedWork W2393310753 @default.
- W2014372409 hasRelatedWork W2555571126 @default.
- W2014372409 hasVolume "35" @default.
- W2014372409 isParatext "false" @default.
- W2014372409 isRetracted "false" @default.
- W2014372409 magId "2014372409" @default.
- W2014372409 workType "article" @default.