FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014372453> ?p ?o ?g. }

• W2014372453 endingPage "e38029" @default.
• W2014372453 startingPage "e38029" @default.
• W2014372453 abstract "The P/Q-type voltage-dependent calcium channels (VDCCs) are essential for synaptic transmission at adult mammalian neuromuscular junctions (NMJs); however, the subsynaptic location of VDCCs relative to active zones in rodent NMJs, and the functional modification of VDCCs by the interaction with active zone protein Bassoon remain unknown. Here, we show that P/Q-type VDCCs distribute in a punctate pattern within the NMJ presynaptic terminals and align in three dimensions with Bassoon. This distribution pattern of P/Q-type VDCCs and Bassoon in NMJs is consistent with our previous study demonstrating the binding of VDCCs and Bassoon. In addition, we now show that the interaction between P/Q-type VDCCs and Bassoon significantly suppressed the inactivation property of P/Q-type VDCCs, suggesting that the Ca2+ influx may be augmented by Bassoon for efficient synaptic transmission at NMJs. However, presynaptic Bassoon level was significantly attenuated in aged rat NMJs, which suggests an attenuation of VDCC function due to a lack of this interaction between VDCC and Bassoon. Importantly, the decreased Bassoon level in aged NMJs was ameliorated by isometric strength training of muscles for two months. The training increased Bassoon immunoreactivity in NMJs without affecting synapse size. These results demonstrated that the P/Q-type VDCCs preferentially accumulate at NMJ active zones and play essential role in synaptic transmission in conjunction with the active zone protein Bassoon. This molecular mechanism becomes impaired by aging, which suggests altered synaptic function in aged NMJs. However, Bassoon level in aged NMJs can be improved by muscle exercise." @default.
• W2014372453 created "2016-06-24" @default.
• W2014372453 creator A5010150569 @default.
• W2014372453 creator A5010479652 @default.
• W2014372453 creator A5014496158 @default.
• W2014372453 creator A5021862429 @default.
• W2014372453 creator A5026117179 @default.
• W2014372453 creator A5041435529 @default.
• W2014372453 creator A5051093832 @default.
• W2014372453 creator A5078967543 @default.
• W2014372453 date "2012-06-06" @default.
• W2014372453 modified "2023-09-25" @default.
• W2014372453 title "Active Zone Protein Bassoon Co-Localizes with Presynaptic Calcium Channel, Modifies Channel Function, and Recovers from Aging Related Loss by Exercise" @default.
• W2014372453 cites W1489731866 @default.
• W2014372453 cites W1526580466 @default.
• W2014372453 cites W1587489391 @default.
• W2014372453 cites W1886290309 @default.
• W2014372453 cites W1964902107 @default.
• W2014372453 cites W1965893090 @default.
• W2014372453 cites W1969308562 @default.
• W2014372453 cites W1969494997 @default.
• W2014372453 cites W1969901709 @default.
• W2014372453 cites W1970723166 @default.
• W2014372453 cites W1970899379 @default.
• W2014372453 cites W1972607225 @default.
• W2014372453 cites W1973841770 @default.
• W2014372453 cites W1974623748 @default.
• W2014372453 cites W1979014198 @default.
• W2014372453 cites W1980032779 @default.
• W2014372453 cites W1981020765 @default.
• W2014372453 cites W1982655462 @default.
• W2014372453 cites W1983169741 @default.
• W2014372453 cites W1989856883 @default.
• W2014372453 cites W1998518207 @default.
• W2014372453 cites W2007953565 @default.
• W2014372453 cites W2014313526 @default.
• W2014372453 cites W2014998003 @default.
• W2014372453 cites W2024808594 @default.
• W2014372453 cites W2026036651 @default.
• W2014372453 cites W2027891453 @default.
• W2014372453 cites W2029122808 @default.
• W2014372453 cites W2030094319 @default.
• W2014372453 cites W2032562864 @default.
• W2014372453 cites W2037812600 @default.
• W2014372453 cites W2039862526 @default.
• W2014372453 cites W2041733763 @default.
• W2014372453 cites W2049580657 @default.
• W2014372453 cites W2050878615 @default.
• W2014372453 cites W2058295628 @default.
• W2014372453 cites W2060946389 @default.
• W2014372453 cites W2064575171 @default.
• W2014372453 cites W2076073835 @default.
• W2014372453 cites W2082386266 @default.
• W2014372453 cites W2093441174 @default.
• W2014372453 cites W2094279273 @default.
• W2014372453 cites W2094955667 @default.
• W2014372453 cites W2096883497 @default.
• W2014372453 cites W2102734706 @default.
• W2014372453 cites W2112522905 @default.
• W2014372453 cites W2115475883 @default.
• W2014372453 cites W2119527348 @default.
• W2014372453 cites W2121896290 @default.
• W2014372453 cites W2124733101 @default.
• W2014372453 cites W2127939995 @default.
• W2014372453 cites W2141412000 @default.
• W2014372453 cites W2151889253 @default.
• W2014372453 cites W2154076074 @default.
• W2014372453 cites W2322652466 @default.
• W2014372453 doi "https://doi.org/10.1371/journal.pone.0038029" @default.
• W2014372453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3368936" @default.
• W2014372453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22701595" @default.
• W2014372453 hasPublicationYear "2012" @default.
• W2014372453 type Work @default.
• W2014372453 sameAs 2014372453 @default.
• W2014372453 citedByCount "47" @default.
• W2014372453 countsByYear W20143724532012 @default.
• W2014372453 countsByYear W20143724532013 @default.
• W2014372453 countsByYear W20143724532014 @default.
• W2014372453 countsByYear W20143724532015 @default.
• W2014372453 countsByYear W20143724532016 @default.
• W2014372453 countsByYear W20143724532017 @default.
• W2014372453 countsByYear W20143724532018 @default.
• W2014372453 countsByYear W20143724532019 @default.
• W2014372453 countsByYear W20143724532020 @default.
• W2014372453 countsByYear W20143724532021 @default.
• W2014372453 countsByYear W20143724532022 @default.
• W2014372453 countsByYear W20143724532023 @default.
• W2014372453 crossrefType "journal-article" @default.
• W2014372453 hasAuthorship W2014372453A5010150569 @default.
• W2014372453 hasAuthorship W2014372453A5010479652 @default.
• W2014372453 hasAuthorship W2014372453A5014496158 @default.
• W2014372453 hasAuthorship W2014372453A5021862429 @default.
• W2014372453 hasAuthorship W2014372453A5026117179 @default.
• W2014372453 hasAuthorship W2014372453A5041435529 @default.
• W2014372453 hasAuthorship W2014372453A5051093832 @default.
• W2014372453 hasAuthorship W2014372453A5078967543 @default.
• W2014372453 hasBestOaLocation W20143724531 @default.
• W2014372453 hasConcept C126322002 @default.

• next