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- W2014372677 abstract "A new cyclic heptapeptide cupolamide A (1) was isolated from two samples of the sponge Theonella cupola collected in Indonesia and Okinawa. It contains two l-Val, one d-Leu, and one d-Ser, and three uncommon amino acid residues, d-homoarginine (Har), trans-4-hydroxy-l-proline (Hyp), and l-2,4-diaminobutanoic acid (Dba). The structure elucidation of 1 was performed by NMR spectroscopic techniques and the stereochemistry was determined by Marfey's method. Cupolamide A (1) was active against P388 murine leukemia cells with an IC50 = 7.5 μg/mL." @default.
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- W2014372677 date "1997-10-01" @default.
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- W2014372677 title "Cupolamide A: A Cytotoxic Cyclic Heptapeptide from Two Samples of the Sponge <i>Theonella cupola</i>" @default.
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- W2014372677 doi "https://doi.org/10.1021/jo9710285" @default.
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