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• W2014373916 abstract "The paucity of organelles in the ultrastructure of the normal resting mammary epithelium indicates that secretory activity is carried out only to a limited extent. A band of avascular stroma surrounds the ducts and ductules and is separated from the vascularized stroma by fibroblasts. There is reason to believe that the structures lying between the epithelium and the delimiting fibroblasts constitute a morphophysiologic unit (epithelial-stromal junction, ESJ) which mediates the transport of materials to and from the epithelium. The ultrastructural and chemical disruption of this ESJ is likely to affect the evolution of dysplastic lesions. Dysplastic epithelium may appear atrophic and hyperplastic or may resemble the ultrastructure of apocrine epithelium. Hyperplastic epithelium shows prominent organelles which in severe hyperplasias resemble the ultrastructural features of carcinoma cells and support the hypothesis that some hyperplasias lead to neoplastic transformation: definite proof however, is lacking. Basically, the ultrastructure of all types of mammary carcinoma cells is characterized by prominent organelles: the frequent variations from cell to cell suggest various functional states of the neoplastic cells. This basic ultrastructure is retained by carcinoma cells cultured in vitro even after heterotransplantation in nude athymic mice. The basal laminae of intraepithelial mammary carcinomas have gaps through which neoplastic cells sometimes protrude into the stroma and give rise to foci of beginning invasion. The smallest of these foci are detectable only with the electron microscope." @default.
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• W2014373916 date "1974-07-01" @default.
• W2014373916 modified "2023-09-29" @default.
• W2014373916 title "Electron Microscopic Study of Functional and Dysfunctional Human Mammary Glands" @default.
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• W2014373916 doi "https://doi.org/10.1111/1523-1747.ep12677303" @default.
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