FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014374003> ?p ?o ?g. }

• W2014374003 endingPage "621" @default.
• W2014374003 startingPage "611" @default.
• W2014374003 abstract "Absorption of bile acids by the distal ileum is an essential component of the enterohepatic circulation. In neonatal rats, the appearance of the apical sodium-dependent bile acid transporter (ASBT) at 17 d of age coincides with increases in serum corticosterone and thyroxine. We tested the hypothesis that these hormones modulate ASBT expression during ileal development. Taurocholate uptake into the isolated ileum of normal 20-d-old pups exhibited saturable (K(m) = 0.52 mM, J(max) = 0.34 pmol mg/min) and nonsaturable (K(diff) = 0.015 min(-1)) components and was two to five times greater than uptake in the proximal intestine. Hypothyroid or euthyroid pups received daily thyroxine injections starting at 6 d of age. At 12 d of age, serum concentrations of thyroxine, ileal abundance of ASBT mRNA, and ileal rates of taurocholate uptake were low in hypothyroid pups that received an injection of vehicle (HT-) or thyroxine (HT+) and in euthyroid pups that received an injection of vehicle (ET-) or thyroxine (ET+). At 20 and 26 d, ileal ASBT mRNA abundance and taurocholate uptake rate remained low in HT- pups but increased dramatically in ET- and ET+ pups, paralleling the increase in serum thyroxine. Restoration of normal plasma thyroxine in HT- pups by thyroxine injections (HT+) restored normal ASBT development. Sodium-glucose co-transporter activity and mRNA expression were independent of serum thyroxine levels. Corticosterone levels were significantly lower in pups that were adrenalectomized at 10 d of age. ASBT mRNA abundance and taurocholate uptake rate increased markedly with age but were the same in adrenalectomized, sham-operated, and nonoperated pups. Hence, endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of ASBT." @default.
• W2014374003 created "2016-06-24" @default.
• W2014374003 creator A5016002022 @default.
• W2014374003 creator A5024341751 @default.
• W2014374003 creator A5069720479 @default.
• W2014374003 date "2004-04-01" @default.
• W2014374003 modified "2023-10-18" @default.
• W2014374003 title "Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone" @default.
• W2014374003 cites W111899358 @default.
• W2014374003 cites W124149417 @default.
• W2014374003 cites W1895895933 @default.
• W2014374003 cites W1914398790 @default.
• W2014374003 cites W1973826150 @default.
• W2014374003 cites W1974719062 @default.
• W2014374003 cites W1980747853 @default.
• W2014374003 cites W1987061137 @default.
• W2014374003 cites W1989887371 @default.
• W2014374003 cites W1993785727 @default.
• W2014374003 cites W1995696280 @default.
• W2014374003 cites W1997414378 @default.
• W2014374003 cites W2002667678 @default.
• W2014374003 cites W2007211505 @default.
• W2014374003 cites W2019275209 @default.
• W2014374003 cites W2019304958 @default.
• W2014374003 cites W2033190611 @default.
• W2014374003 cites W2059741646 @default.
• W2014374003 cites W2064060167 @default.
• W2014374003 cites W2064572248 @default.
• W2014374003 cites W2069472359 @default.
• W2014374003 cites W2080765470 @default.
• W2014374003 cites W2084585029 @default.
• W2014374003 cites W2090836208 @default.
• W2014374003 cites W2093571167 @default.
• W2014374003 cites W2106520767 @default.
• W2014374003 cites W2159851918 @default.
• W2014374003 cites W2319927537 @default.
• W2014374003 cites W2406245147 @default.
• W2014374003 cites W2419307543 @default.
• W2014374003 cites W304016200 @default.
• W2014374003 cites W4294216491 @default.
• W2014374003 cites W2006865313 @default.
• W2014374003 doi "https://doi.org/10.1203/01.pdr.0000112126.07230.9a" @default.
• W2014374003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14711893" @default.
• W2014374003 hasPublicationYear "2004" @default.
• W2014374003 type Work @default.
• W2014374003 sameAs 2014374003 @default.
• W2014374003 citedByCount "9" @default.
• W2014374003 countsByYear W20143740032017 @default.
• W2014374003 countsByYear W20143740032019 @default.
• W2014374003 crossrefType "journal-article" @default.
• W2014374003 hasAuthorship W2014374003A5016002022 @default.
• W2014374003 hasAuthorship W2014374003A5024341751 @default.
• W2014374003 hasAuthorship W2014374003A5069720479 @default.
• W2014374003 hasBestOaLocation W20143740031 @default.
• W2014374003 hasConcept C126322002 @default.
• W2014374003 hasConcept C134018914 @default.
• W2014374003 hasConcept C185592680 @default.
• W2014374003 hasConcept C2777195454 @default.
• W2014374003 hasConcept C2777226302 @default.
• W2014374003 hasConcept C2778620825 @default.
• W2014374003 hasConcept C2779399885 @default.
• W2014374003 hasConcept C2780352252 @default.
• W2014374003 hasConcept C2780480987 @default.
• W2014374003 hasConcept C71315377 @default.
• W2014374003 hasConcept C71924100 @default.
• W2014374003 hasConcept C86803240 @default.
• W2014374003 hasConceptScore W2014374003C126322002 @default.
• W2014374003 hasConceptScore W2014374003C134018914 @default.
• W2014374003 hasConceptScore W2014374003C185592680 @default.
• W2014374003 hasConceptScore W2014374003C2777195454 @default.
• W2014374003 hasConceptScore W2014374003C2777226302 @default.
• W2014374003 hasConceptScore W2014374003C2778620825 @default.
• W2014374003 hasConceptScore W2014374003C2779399885 @default.
• W2014374003 hasConceptScore W2014374003C2780352252 @default.
• W2014374003 hasConceptScore W2014374003C2780480987 @default.
• W2014374003 hasConceptScore W2014374003C71315377 @default.
• W2014374003 hasConceptScore W2014374003C71924100 @default.
• W2014374003 hasConceptScore W2014374003C86803240 @default.
• W2014374003 hasIssue "4" @default.
• W2014374003 hasLocation W20143740031 @default.
• W2014374003 hasLocation W20143740032 @default.
• W2014374003 hasOpenAccess W2014374003 @default.
• W2014374003 hasPrimaryLocation W20143740031 @default.
• W2014374003 hasRelatedWork W1973859193 @default.
• W2014374003 hasRelatedWork W2014374003 @default.
• W2014374003 hasRelatedWork W2066415402 @default.
• W2014374003 hasRelatedWork W2081351255 @default.
• W2014374003 hasRelatedWork W2083970607 @default.
• W2014374003 hasRelatedWork W2097476982 @default.
• W2014374003 hasRelatedWork W2122474899 @default.
• W2014374003 hasRelatedWork W2144241495 @default.
• W2014374003 hasRelatedWork W2163373810 @default.
• W2014374003 hasRelatedWork W2239019102 @default.
• W2014374003 hasVolume "55" @default.
• W2014374003 isParatext "false" @default.
• W2014374003 isRetracted "false" @default.
• W2014374003 magId "2014374003" @default.
• W2014374003 workType "article" @default.