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- W2014374088 abstract "Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor β1 (IL-12Rβ1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recent study showed that macrophages express IL-23R mRNA and can be distinguished from microglia by IL-23R expression. However, in this study, we show by RT-PCR and immunocytochemistry that microglia express IL-23R and IL-12Rβ1 mRNA and protein, respectively. Additionally, microglia expressed a functional receptor for IL-23, as IL-23 enhanced the Interferon (IFN)-γ-induced signal transducer and activator of transcription (STAT)1 phosphorylation and chemokine production. Thus, IL-23R expression does not discriminate peripheral macrophages from microglia. Moreover, since microglia produce IL-23, it may function in an autocrine manner to recruit inflammatory cells by inducing chemokine production." @default.
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- W2014374088 date "2008-01-01" @default.
- W2014374088 modified "2023-10-16" @default.
- W2014374088 title "OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation" @default.
- W2014374088 doi "https://doi.org/10.1016/j.clim.2008.03.046" @default.
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