Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014374504> ?p ?o ?g. }
- W2014374504 abstract "Integrins play an important role in tumor dissemination. The purpose of this study was to examine whether a SH-reactive reagent inhibits the adhesion of the human pancreatic cancer cell line AsPC-1 to extracellular matrix components. Activated lansoprazole (AG-2000) was used as the SH-reactive reagent because this compound is known to react with SH groups but does not permeate the cell membrane. The effect of AG-2000 on the adhesion of AsPC-1 cells to matrix was examined, using both an in vitro adhesion assay and an in vivo nude mouse xenograft model of peritoneal implantation. In the in vitro adhesion assay, a 60-min exposure of AsPC-1 cells to AG-2000 resulted in a dose-dependent inhibition of AsPC-1 cell adhesion to laminin, fibronectin and type IV collagen, although AG-2000 did not affect the viability of AsPC-1 cells by MTT assay. In the in vivo assessment of AsPC-1 cell implantation, the AsPC-1 cells were initially preincubated with AG-2000 for 60 min to ensure adequate exposure of the AsPC-1 cells to AG-2000 before intraperitoneal injection. AG-2000 significantly inhibited the peritoneal implantation of the AsPC-1 cells in nude mice. These findings suggest that a short exposure of cancer cells to AG-2000 can inhibit cancer cell adhesion to extracellular matrix components." @default.
- W2014374504 created "2016-06-24" @default.
- W2014374504 creator A5006113916 @default.
- W2014374504 creator A5008737850 @default.
- W2014374504 creator A5009888954 @default.
- W2014374504 creator A5011681054 @default.
- W2014374504 creator A5024644803 @default.
- W2014374504 creator A5041813863 @default.
- W2014374504 creator A5042147058 @default.
- W2014374504 creator A5042317745 @default.
- W2014374504 creator A5056134258 @default.
- W2014374504 creator A5056226936 @default.
- W2014374504 creator A5064622871 @default.
- W2014374504 creator A5071891873 @default.
- W2014374504 creator A5089533787 @default.
- W2014374504 date "1999-07-01" @default.
- W2014374504 modified "2023-10-18" @default.
- W2014374504 title "Activated lansoprazole inhibits cancer cell adhesion to extracellular matrix components." @default.
- W2014374504 doi "https://doi.org/10.3892/ijo.15.1.33" @default.
- W2014374504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10375591" @default.
- W2014374504 hasPublicationYear "1999" @default.
- W2014374504 type Work @default.
- W2014374504 sameAs 2014374504 @default.
- W2014374504 citedByCount "6" @default.
- W2014374504 countsByYear W20143745042016 @default.
- W2014374504 countsByYear W20143745042020 @default.
- W2014374504 countsByYear W20143745042022 @default.
- W2014374504 crossrefType "journal-article" @default.
- W2014374504 hasAuthorship W2014374504A5006113916 @default.
- W2014374504 hasAuthorship W2014374504A5008737850 @default.
- W2014374504 hasAuthorship W2014374504A5009888954 @default.
- W2014374504 hasAuthorship W2014374504A5011681054 @default.
- W2014374504 hasAuthorship W2014374504A5024644803 @default.
- W2014374504 hasAuthorship W2014374504A5041813863 @default.
- W2014374504 hasAuthorship W2014374504A5042147058 @default.
- W2014374504 hasAuthorship W2014374504A5042317745 @default.
- W2014374504 hasAuthorship W2014374504A5056134258 @default.
- W2014374504 hasAuthorship W2014374504A5056226936 @default.
- W2014374504 hasAuthorship W2014374504A5064622871 @default.
- W2014374504 hasAuthorship W2014374504A5071891873 @default.
- W2014374504 hasAuthorship W2014374504A5089533787 @default.
- W2014374504 hasConcept C121608353 @default.
- W2014374504 hasConcept C126322002 @default.
- W2014374504 hasConcept C1491633281 @default.
- W2014374504 hasConcept C150903083 @default.
- W2014374504 hasConcept C153911025 @default.
- W2014374504 hasConcept C16224149 @default.
- W2014374504 hasConcept C178790620 @default.
- W2014374504 hasConcept C185592680 @default.
- W2014374504 hasConcept C189165786 @default.
- W2014374504 hasConcept C195687474 @default.
- W2014374504 hasConcept C203014093 @default.
- W2014374504 hasConcept C207001950 @default.
- W2014374504 hasConcept C2779814568 @default.
- W2014374504 hasConcept C502942594 @default.
- W2014374504 hasConcept C53227056 @default.
- W2014374504 hasConcept C55493867 @default.
- W2014374504 hasConcept C71924100 @default.
- W2014374504 hasConcept C84416704 @default.
- W2014374504 hasConcept C85789140 @default.
- W2014374504 hasConcept C86492073 @default.
- W2014374504 hasConcept C86803240 @default.
- W2014374504 hasConcept C95444343 @default.
- W2014374504 hasConcept C96232424 @default.
- W2014374504 hasConceptScore W2014374504C121608353 @default.
- W2014374504 hasConceptScore W2014374504C126322002 @default.
- W2014374504 hasConceptScore W2014374504C1491633281 @default.
- W2014374504 hasConceptScore W2014374504C150903083 @default.
- W2014374504 hasConceptScore W2014374504C153911025 @default.
- W2014374504 hasConceptScore W2014374504C16224149 @default.
- W2014374504 hasConceptScore W2014374504C178790620 @default.
- W2014374504 hasConceptScore W2014374504C185592680 @default.
- W2014374504 hasConceptScore W2014374504C189165786 @default.
- W2014374504 hasConceptScore W2014374504C195687474 @default.
- W2014374504 hasConceptScore W2014374504C203014093 @default.
- W2014374504 hasConceptScore W2014374504C207001950 @default.
- W2014374504 hasConceptScore W2014374504C2779814568 @default.
- W2014374504 hasConceptScore W2014374504C502942594 @default.
- W2014374504 hasConceptScore W2014374504C53227056 @default.
- W2014374504 hasConceptScore W2014374504C55493867 @default.
- W2014374504 hasConceptScore W2014374504C71924100 @default.
- W2014374504 hasConceptScore W2014374504C84416704 @default.
- W2014374504 hasConceptScore W2014374504C85789140 @default.
- W2014374504 hasConceptScore W2014374504C86492073 @default.
- W2014374504 hasConceptScore W2014374504C86803240 @default.
- W2014374504 hasConceptScore W2014374504C95444343 @default.
- W2014374504 hasConceptScore W2014374504C96232424 @default.
- W2014374504 hasLocation W20143745041 @default.
- W2014374504 hasLocation W20143745042 @default.
- W2014374504 hasOpenAccess W2014374504 @default.
- W2014374504 hasPrimaryLocation W20143745041 @default.
- W2014374504 hasRelatedWork W1974956317 @default.
- W2014374504 hasRelatedWork W1994634008 @default.
- W2014374504 hasRelatedWork W1996296303 @default.
- W2014374504 hasRelatedWork W2056589302 @default.
- W2014374504 hasRelatedWork W2074507788 @default.
- W2014374504 hasRelatedWork W2085544165 @default.
- W2014374504 hasRelatedWork W2109604562 @default.
- W2014374504 hasRelatedWork W2169798061 @default.
- W2014374504 hasRelatedWork W2172225965 @default.