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- W2014374919 abstract "A long-standing ambiguity has been whether quiescent cells located in intestinal crypt structures are stem cells. The answer seems to be yes and no, depending on how one defines the term stem cell. See Article p.65 Whether slowly cycling or quiescent stem cells co-exist with more rapidly cycling stem cells in the intestinal crypt is a matter of intense debate. Using a new method to trace the lineage of slowly cycling label-retaining cells (LRCs) in vivo, Douglas Winton and colleagues have identified a population of LRCs that has features of committed Paneth cells but still expresses stem cell markers such as Lgr5. The slowly cycling cells differentiate into Paneth cells without cell division, but in response to injury, they can also repopulate the stem cell niche and contribute to the regeneration of the all intestinal lineages. This work suggests that quiescent cells do act as a clonogenic reserve that could play a part in the pathology of intestinal cancers and inflammation." @default.
- W2014374919 created "2016-06-24" @default.
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- W2014374919 date "2013-02-27" @default.
- W2014374919 modified "2023-09-28" @default.
- W2014374919 title "A unifying theory for the crypt" @default.
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- W2014374919 doi "https://doi.org/10.1038/nature11958" @default.
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