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- W2014375196 abstract "Accumulating evidence suggests exercise preserves cognitive vitality in the elderly. Brain erythropoietin (EPO) is putatively neuroprotective and may be upregulated by intermittent altitude exposure. PURPOSE: We tested the hypothesis that a novel living high-training low exercise strategy upregulates blood and cerebrospinal fluid (CSF) EPO levels and improves cardiorespiratory fitness in patients with early Alzheimer's disease (AD) or mild cognitive impairment (MCI). METHODS: Five patients with early AD or MCI (4m/1f, mean age 66) and 3 healthy control subjects (3f, mean age 63) were studied before and after a 5 week intervention of aerobic exercise training at sea level during the day and sleeping in an altitude tent at night. The simulated altitude level was approximately 8,200 ft (2,500 m). Each subject also performed exercise testing to determine their VO2max before and after the intervention. Oxygen uptake was measured via the Douglas Bag method. A moderate intensity exercise training program was prescribed for each individual based on his/her fitness level. Plasma and CSF EPO were measured with ELISA. Blood volume and hemoglobin mass were measured using CO rebreathing. RESULTS: (see table) VO2max increased significantly by 9% after the intervention in patients with AD or MCI, but not in controls. CSF and blood EPO increased by 11% and 59% respectively associated with no increase in hemoglobin mass. CONCLUSIONS: Living high-training low increased blood and CSF EPO associated with improved cardiorespiratory fitness in patients with early AD or MCI.TableSupported in part by UT Southwestern Alzheimer's Disease Center pilot study award NIH P30 AG12300 and Southwestern Medical Foundation." @default.
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- W2014375196 date "2010-05-01" @default.
- W2014375196 modified "2023-09-26" @default.
- W2014375196 title "Living High-Training Low Improves Exercise Capacity in Patients with Alzheimer's Disease and Mild Cognitive Impairment" @default.
- W2014375196 doi "https://doi.org/10.1249/01.mss.0000385542.36993.b8" @default.
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