FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014376812> ?p ?o ?g. }

• W2014376812 endingPage "3317" @default.
• W2014376812 startingPage "3312" @default.
• W2014376812 abstract "Mitochondrial ATP-sensitive K (mitoK ATP ) channels play a central role in protecting the heart from injury in ischemic preconditioning. In isolated mitochondria exposed to elevated extramitochondrial Ca, P i , and anoxia to simulate ischemic conditions, the selective mitoK ATP channel agonist diazoxide (25–50 μM) potently reduced mitochondrial injury by preventing both the mitochondrial permeability transition (MPT) and cytochrome c loss from the intermembrane space. Both effects were blocked completely by the selective mitoK ATP antagonist 5-hydroxydecanoate. The protective effect against Ca-induced MPT was most evident under conditions in which the ability of electron transport to support membrane potential (Δψ m ) was decreased and inner membrane leakiness was increased moderately. Under these conditions, mitoK ATP channel activity strongly regulated Δψ m , and diazoxide prevented MPT by inhibiting the driving force for Ca uptake. Phorbol 12-myristate 13-acetate mimicked the protective effects of diazoxide, unless 5-hydroxydecanoate was present, indicating that protein kinase C activation also protects mitochondria by activating mitoK ATP channels. Because Δψ m recovery ultimately is required for heart functional recovery, these results may explain how mitoK ATP channel activation mimics ischemic preconditioning by protecting mitochondria as they pass through a critical vulnerability window during ischemia/reperfusion." @default.
• W2014376812 created "2016-06-24" @default.
• W2014376812 creator A5009561014 @default.
• W2014376812 creator A5029391633 @default.
• W2014376812 creator A5035883737 @default.
• W2014376812 date "2002-02-26" @default.
• W2014376812 modified "2023-09-25" @default.
• W2014376812 title "Protection of cardiac mitochondria by diazoxide and protein kinase C: Implications for ischemic preconditioning" @default.
• W2014376812 cites W1548755019 @default.
• W2014376812 cites W1581717960 @default.
• W2014376812 cites W1755643459 @default.
• W2014376812 cites W1965101612 @default.
• W2014376812 cites W1969606703 @default.
• W2014376812 cites W1977364230 @default.
• W2014376812 cites W1980307873 @default.
• W2014376812 cites W1984269223 @default.
• W2014376812 cites W1986480651 @default.
• W2014376812 cites W1989633392 @default.
• W2014376812 cites W1993353490 @default.
• W2014376812 cites W2007294454 @default.
• W2014376812 cites W2007939778 @default.
• W2014376812 cites W2008485444 @default.
• W2014376812 cites W2014399713 @default.
• W2014376812 cites W2063385957 @default.
• W2014376812 cites W2066334661 @default.
• W2014376812 cites W2111975835 @default.
• W2014376812 cites W2121962823 @default.
• W2014376812 cites W2124027170 @default.
• W2014376812 cites W2133726443 @default.
• W2014376812 cites W2151126528 @default.
• W2014376812 cites W2158350888 @default.
• W2014376812 cites W2160153843 @default.
• W2014376812 cites W2168717950 @default.
• W2014376812 cites W2184484397 @default.
• W2014376812 cites W2186345844 @default.
• W2014376812 cites W2231430380 @default.
• W2014376812 cites W2237730056 @default.
• W2014376812 cites W2280577476 @default.
• W2014376812 cites W4250699570 @default.
• W2014376812 doi "https://doi.org/10.1073/pnas.052713199" @default.
• W2014376812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/122515" @default.
• W2014376812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11867760" @default.
• W2014376812 hasPublicationYear "2002" @default.
• W2014376812 type Work @default.
• W2014376812 sameAs 2014376812 @default.
• W2014376812 citedByCount "172" @default.
• W2014376812 countsByYear W20143768122012 @default.
• W2014376812 countsByYear W20143768122013 @default.
• W2014376812 countsByYear W20143768122014 @default.
• W2014376812 countsByYear W20143768122015 @default.
• W2014376812 countsByYear W20143768122016 @default.
• W2014376812 countsByYear W20143768122017 @default.
• W2014376812 countsByYear W20143768122018 @default.
• W2014376812 countsByYear W20143768122019 @default.
• W2014376812 countsByYear W20143768122020 @default.
• W2014376812 countsByYear W20143768122021 @default.
• W2014376812 countsByYear W20143768122022 @default.
• W2014376812 countsByYear W20143768122023 @default.
• W2014376812 crossrefType "journal-article" @default.
• W2014376812 hasAuthorship W2014376812A5009561014 @default.
• W2014376812 hasAuthorship W2014376812A5029391633 @default.
• W2014376812 hasAuthorship W2014376812A5035883737 @default.
• W2014376812 hasBestOaLocation W20143768122 @default.
• W2014376812 hasConcept C12554922 @default.
• W2014376812 hasConcept C126322002 @default.
• W2014376812 hasConcept C134018914 @default.
• W2014376812 hasConcept C13591479 @default.
• W2014376812 hasConcept C181911157 @default.
• W2014376812 hasConcept C185592680 @default.
• W2014376812 hasConcept C190283241 @default.
• W2014376812 hasConcept C2779306644 @default.
• W2014376812 hasConcept C2779311647 @default.
• W2014376812 hasConcept C2779872217 @default.
• W2014376812 hasConcept C28859421 @default.
• W2014376812 hasConcept C31573885 @default.
• W2014376812 hasConcept C541997718 @default.
• W2014376812 hasConcept C55493867 @default.
• W2014376812 hasConcept C71924100 @default.
• W2014376812 hasConcept C75385678 @default.
• W2014376812 hasConcept C86803240 @default.
• W2014376812 hasConcept C95444343 @default.
• W2014376812 hasConcept C98274493 @default.
• W2014376812 hasConceptScore W2014376812C12554922 @default.
• W2014376812 hasConceptScore W2014376812C126322002 @default.
• W2014376812 hasConceptScore W2014376812C134018914 @default.
• W2014376812 hasConceptScore W2014376812C13591479 @default.
• W2014376812 hasConceptScore W2014376812C181911157 @default.
• W2014376812 hasConceptScore W2014376812C185592680 @default.
• W2014376812 hasConceptScore W2014376812C190283241 @default.
• W2014376812 hasConceptScore W2014376812C2779306644 @default.
• W2014376812 hasConceptScore W2014376812C2779311647 @default.
• W2014376812 hasConceptScore W2014376812C2779872217 @default.
• W2014376812 hasConceptScore W2014376812C28859421 @default.
• W2014376812 hasConceptScore W2014376812C31573885 @default.
• W2014376812 hasConceptScore W2014376812C541997718 @default.
• W2014376812 hasConceptScore W2014376812C55493867 @default.
• W2014376812 hasConceptScore W2014376812C71924100 @default.
• W2014376812 hasConceptScore W2014376812C75385678 @default.

• next